CAJ | 학술논문

目的：探讨胰岛素样生长因子-l(IGF-l)及其受体(IGF-lR)在大肠癌发病机制中的作用及临床意义。方法：应用免疫组化染色法检测50例大肠癌组织、20例大肠腺瘤和20例正常大肠黏膜中IGF-1和IGF-lR蛋白的表达水平。结果：大肠正常黏膜、腺瘤及癌组织IGF-1、IGF-1R的表达水平逐渐升高，组间比较差异具有统计学意义(P＜0.01)。大肠癌组织中，IGF-1和IGF-1R的表达呈正相关(r=0.585，P＜0.01)。结论：IGF-1R和IGF-1在大肠癌的发生发展中具有重要作用。
목적：탐토이도소양생장인자-l(IGF-l)급기수체(IGF-lR)재대장암발병궤제중적작용급림상의의。방법：응용면역조화염색법검측50례대장암조직、20례대장선류화20례정상대장점막중IGF-1화IGF-lR단백적표체수평。결과：대장정상점막、선류급암조직IGF-1、IGF-1R적표체수평축점승고，조간비교차이구유통계학의의(P＜0.01)。대장암조직중，IGF-1화IGF-1R적표체정정상관(r=0.585，P＜0.01)。결론：IGF-1R화IGF-1재대장암적발생발전중구유중요작용。
Objective:To investigate the expression and clinical significance of insulin-like growth factor-1 (IGF-1) andinsulin-likegrowthfactor-1receptor(IGF-1R)inpathogenesisofcolorectalcarcinomas.Methods:Immunohistochemical method was used to detect the expression of IGF-1 and IGF-1R protein in 50 cases colorectal carcinomas, 20 cases colorectal adenoma and 20 cases normal colorectal mucosa. Results:From normal colorectal mucosa, colorectal adenoma to colorectal carcinomas, the expression of IGF-1 and IGF-1R protein gradually increased (P<0.01). In colorectal carcinomas, the expression of IGF-1 and IGF-1R had positive correlations (r=0.585, P<0.01).Conclusions:IGF-1 and IGF-1R may play an important roleindevelopmentofcolorectalcarcinomas.