CAJ | 학술논문

目的：探讨骨巨细胞瘤(GCT)中埃兹(Ezrin)蛋白的表达及其与GCT临床病理参数的关系。方法：采用SP免疫组化法检测75例GCT中Ezrin蛋白的表达，并分析其与GCT临床病理参数的关系。结果：Ezrin在GCT中的阳性表达率按临床影像学分级分别为Ⅰ级13.3%、Ⅱ级33.3%、Ⅲ级80.0%。GCT中Ezrin的阳性表达率与患者的年龄、性别以及病理分期无关(P＞0.05)，与GCT的临床影像学分级有关(P＜0.01)。结论：Ezrin可作为判断GCT局部浸润的指标，从而为GCT的临床治疗提供帮助。
목적：탐토골거세포류(GCT)중애자(Ezrin)단백적표체급기여GCT림상병리삼수적관계。방법：채용SP면역조화법검측75례GCT중Ezrin단백적표체，병분석기여GCT림상병리삼수적관계。결과：Ezrin재GCT중적양성표체솔안림상영상학분급분별위Ⅰ급13.3%、Ⅱ급33.3%、Ⅲ급80.0%。GCT중Ezrin적양성표체솔여환자적년령、성별이급병리분기무관(P＞0.05)，여GCT적림상영상학분급유관(P＜0.01)。결론：Ezrin가작위판단GCT국부침윤적지표，종이위GCT적림상치료제공방조。
Objective:To explore the expression of Ezrin in giant cell tumor (GCT) and its relationships with clinicopathological parameters of GCT.Methods:SP immunohistochemical method was used to detect the expression of Ezrin in 75 cases GCT and analyze its relationships with clinicopathological parameters of GCT.Results:The positive expression rate of Ezrin in GCT was 13.3%(gradeⅠ), 33.3%(gradeⅡ) and 80.0%(gradeⅢ), which was not related with age, sex and pathological stage (P>0.05), but related with radiographic grade (P<0.01). Conclusions:Ezrin can be acted as index to judge local invasion of GCT, and provide help for clinical treatment of GCT.