中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
2期
63-66
,共4页
小儿原发性肾病综合征%激素治疗%淋巴细胞%影响分析
小兒原髮性腎病綜閤徵%激素治療%淋巴細胞%影響分析
소인원발성신병종합정%격소치료%림파세포%영향분석
Children with primary nephrotic syndrome%Hormone therapy%Lymphocytes%The impact analysis
目的：探讨激素治疗小儿原发性肾病综合征对淋巴细胞产生的影响。方法将本院儿科2012年6月至2013年6月诊断和治疗的原发性肾病综合征并且正在行激素治疗的患儿50例作为病例组，同时选取本院检查健康的40例儿童作为对照组，分别应用流式细胞术测量患儿的淋巴细胞系，比较两组检查的结果。结果病例组CD3＋、CD3＋CD4＋、CD4＋CD25＋、NK细胞含量与对照组相比都有所下降，差异均具有显著性（P＜0.05），CD3＋CD8＋、B细胞含量与对照组相比均升高，差异具有显著性（P＜0.05）；治疗后上述指标改善，CD3＋CD4＋和B细胞的含量在两组之间的差异具有显著性（P＜0.05）。结论激素治疗小儿原发性肾病综合征对淋巴细胞系产生一定的影响，起一定的治疗作用。
目的：探討激素治療小兒原髮性腎病綜閤徵對淋巴細胞產生的影響。方法將本院兒科2012年6月至2013年6月診斷和治療的原髮性腎病綜閤徵併且正在行激素治療的患兒50例作為病例組，同時選取本院檢查健康的40例兒童作為對照組，分彆應用流式細胞術測量患兒的淋巴細胞繫，比較兩組檢查的結果。結果病例組CD3＋、CD3＋CD4＋、CD4＋CD25＋、NK細胞含量與對照組相比都有所下降，差異均具有顯著性（P＜0.05），CD3＋CD8＋、B細胞含量與對照組相比均升高，差異具有顯著性（P＜0.05）；治療後上述指標改善，CD3＋CD4＋和B細胞的含量在兩組之間的差異具有顯著性（P＜0.05）。結論激素治療小兒原髮性腎病綜閤徵對淋巴細胞繫產生一定的影響，起一定的治療作用。
목적：탐토격소치료소인원발성신병종합정대림파세포산생적영향。방법장본원인과2012년6월지2013년6월진단화치료적원발성신병종합정병차정재행격소치료적환인50례작위병례조，동시선취본원검사건강적40례인동작위대조조，분별응용류식세포술측량환인적림파세포계，비교량조검사적결과。결과병례조CD3＋、CD3＋CD4＋、CD4＋CD25＋、NK세포함량여대조조상비도유소하강，차이균구유현저성（P＜0.05），CD3＋CD8＋、B세포함량여대조조상비균승고，차이구유현저성（P＜0.05）；치료후상술지표개선，CD3＋CD4＋화B세포적함량재량조지간적차이구유현저성（P＜0.05）。결론격소치료소인원발성신병종합정대림파세포계산생일정적영향，기일정적치료작용。
Objective To study the effect of pediatric primary nephrotic syndrome hormone therapy on lymphocytes induced. Methods The diagnosis and treatment of the pediatric department of our hospital from 2012 June to 2013 June in primary nephrotic syndrome and is hormonal treatment in 50 cases as case group, at the same time, the selection of the institute of child health examination in 40 cases as control group (placebo control), lfow cytometry measurements were compared between the two groups of cell lines examined results. Results Cases in treatment group and control group before the lymphoid cell line comparison shows that the parts of CD3+and CD3+, CD4+, CD4+CD25+and NK cells were decreased compared with control group differences were statistically signiifcant (P<0.05), the CD3+CD8+, B cells are elevated compared with control group, difference has statistical signiifcance (P < 0.05);after treatment the levels are changes to the normal values, compared with the control group after treatment of CD3+, CD4+and the content of B cells in the difference between the two groups have statistical signiifcance (P<0.05). Conclusion Hormone treatment children with primary nephrotic syndrome of lymphoid cell lines have influence, plays a certain therapeutic effect.
