新医学
新醫學
신의학
NEW CHINESE MEDICINE
2014年
2期
127-130
,共4页
冯冰瑜%刘凯%孙娜%朱焰%姜武林
馮冰瑜%劉凱%孫娜%硃燄%薑武林
풍빙유%류개%손나%주염%강무림
川崎病%临床特点%诊断%治疗
川崎病%臨床特點%診斷%治療
천기병%림상특점%진단%치료
Kawasaki disease%Clinical features%Diagnosis%Treatment
目的:比较川崎病(KD)与不完全川崎病(iKD)临床特点差异。方法通过多中心观察性研究,收集2007年至2012年湖州市第一人民医院,辽河油田中心医院,慈溪市人民医院3家三甲医院收治的234例KD患儿及48例iKD患儿临床资料。分析其临床特点和转归情况,比较两者临床特点差异。结果KD组患儿手足硬肿、指趾端脱皮、多形性红斑、眼结膜充血、口唇充血皲裂、草莓舌、颈部淋巴结肿大发生率均明显高于iKD组(P均<0.05),且KD组患儿以发热、球结合膜充血最常见,而 iKD组主要为指趾端脱皮及手足硬肿。KD组患儿中血红蛋白下降者及白细胞增多者比例高于iKD组,iKD组患儿中心肌酶升高者比例高于KD组(P均<0.01)。KD组患儿多以多形性红斑为首发症状,而iKD较早出现的症状为球结合膜充血。iKD组患儿心电图检查示急性期窦性心动过速者比例高于KD组(P<0.01)。iKD组对IVIG治疗不敏感者比例高于KD组(P<0.01)。结论KD和iKD在临床表现和预后不尽相同,在诊疗是应积极分开对待。
目的:比較川崎病(KD)與不完全川崎病(iKD)臨床特點差異。方法通過多中心觀察性研究,收集2007年至2012年湖州市第一人民醫院,遼河油田中心醫院,慈溪市人民醫院3傢三甲醫院收治的234例KD患兒及48例iKD患兒臨床資料。分析其臨床特點和轉歸情況,比較兩者臨床特點差異。結果KD組患兒手足硬腫、指趾耑脫皮、多形性紅斑、眼結膜充血、口脣充血皸裂、草莓舌、頸部淋巴結腫大髮生率均明顯高于iKD組(P均<0.05),且KD組患兒以髮熱、毬結閤膜充血最常見,而 iKD組主要為指趾耑脫皮及手足硬腫。KD組患兒中血紅蛋白下降者及白細胞增多者比例高于iKD組,iKD組患兒中心肌酶升高者比例高于KD組(P均<0.01)。KD組患兒多以多形性紅斑為首髮癥狀,而iKD較早齣現的癥狀為毬結閤膜充血。iKD組患兒心電圖檢查示急性期竇性心動過速者比例高于KD組(P<0.01)。iKD組對IVIG治療不敏感者比例高于KD組(P<0.01)。結論KD和iKD在臨床錶現和預後不儘相同,在診療是應積極分開對待。
목적:비교천기병(KD)여불완전천기병(iKD)림상특점차이。방법통과다중심관찰성연구,수집2007년지2012년호주시제일인민의원,료하유전중심의원,자계시인민의원3가삼갑의원수치적234례KD환인급48례iKD환인림상자료。분석기림상특점화전귀정황,비교량자림상특점차이。결과KD조환인수족경종、지지단탈피、다형성홍반、안결막충혈、구진충혈군렬、초매설、경부림파결종대발생솔균명현고우iKD조(P균<0.05),차KD조환인이발열、구결합막충혈최상견,이 iKD조주요위지지단탈피급수족경종。KD조환인중혈홍단백하강자급백세포증다자비례고우iKD조,iKD조환인중심기매승고자비례고우KD조(P균<0.01)。KD조환인다이다형성홍반위수발증상,이iKD교조출현적증상위구결합막충혈。iKD조환인심전도검사시급성기두성심동과속자비례고우KD조(P<0.01)。iKD조대IVIG치료불민감자비례고우KD조(P<0.01)。결론KD화iKD재림상표현화예후불진상동,재진료시응적겁분개대대。
Objective To compare the difference of clinical features between Kawasaki disease (KD)and incomplete Kawasaki disease (iKD).Methods In this multicenter study,234 cases of KD and 48 cases of iKD from January 2007 to December 201 2 were collected in the First People’s Hospital of Huzhou City, Liaohe Oilfield Central Hospital and People’s Hospital of Cixi City.The clinical features of KD and iKD were analyzed and compared.Results The incidence of children with hand,foot hard swollen,peelings in fingers and toes,erythema multiforme,conjunctival hyperemia,congestion and chapped lips,strawberry tongue,cer-vical lymph nodes in KD group was significantly higher than that in iKD group (P<0.05).Fever and ball conjunctival hyperemia were the most common symptoms in KD group.And major manifestations in iKD group were fingers and toes end peeling and swelling of hands and feet,while other symptoms were relatively rare.In addition,most children in KD group presented erythema multiforme as the first symptom,while the earlier symptom of iKD was ball conjunctival hyperemia.The incidences of hemoglobin decrease and leukocytosis in KD group were significantly higher than those in iKD group.The abnormal level of CK-MB in iKD group ap-peared significantly higher than that in KD.Abnormal ECG was more frequently observed in iKD group.The ratio of no response to IVIG therapy in iKD group was higher than that in KD Group.Conclusions The clini-cal manifestations and prognosis varied between KD and iKD,which should be treated separately.