CAJ | 학술논문

目的：探讨高危型HPV基因分型检测结合液基细胞学检查在宫颈癌前病变诊断中的应用。方法纳入204例宫颈癌患者，采集液基细胞标本后，进行高危型HPV基因分型检测，并与宫颈活检结果进行比较分析。结果138例患者显示TCT阳性合并HPV感染，其中LSIL显示HPV阳性40例（29．0％），HSIL显示HPV阳性10例（7．2％），AS-CUS显示HPV阳性80例（58．0％），SCC显示HPV阳性8例（5．8％）。42例HPV高危型，阳性率为30．4％。不同类型标本HPV高危型感染率具有显著性差异（ P＜0．05）。 TCT和HPV均为（-）时，则未发生高度病变。 HPV阳性和TCT异常同时存在时，≥CINⅠ的检出率为34．8％。仅TCT异常而HPV（-）时，检出率为47．8％。结论高危型HPV基因分型检测结合液基细胞学检查是极具价值的宫颈癌早期筛查方法，联合检测比单项检查更可靠。
목적：탐토고위형HPV기인분형검측결합액기세포학검사재궁경암전병변진단중적응용。방법납입204례궁경암환자，채집액기세포표본후，진행고위형HPV기인분형검측，병여궁경활검결과진행비교분석。결과138례환자현시TCT양성합병HPV감염，기중LSIL현시HPV양성40례（29．0％），HSIL현시HPV양성10례（7．2％），AS-CUS현시HPV양성80례（58．0％），SCC현시HPV양성8례（5．8％）。42례HPV고위형，양성솔위30．4％。불동류형표본HPV고위형감염솔구유현저성차이（ P＜0．05）。 TCT화HPV균위（-）시，칙미발생고도병변。 HPV양성화TCT이상동시존재시，≥CINⅠ적검출솔위34．8％。부TCT이상이HPV（-）시，검출솔위47．8％。결론고위형HPV기인분형검측결합액기세포학검사시겁구개치적궁경암조기사사방법，연합검측비단항검사경가고。
Objective To investigate the application of high-risk HPV genotyping assay combined with liquid-based cy-tology for cervical lesions .Methods Liquid-based cytology samples of 204 cases of cervical cancer were detected by high-risk HPV genotyping assay ,and were compared with cervical biopsy results .Results 138 patients were TCT-positive combined with HPV infection,LSIL showed that HPV-positive was 40 cases (29.0%),HSIL showed that HPV-positive was 10 cases (7.2%), ASCUS showed that HPV-positive was 80 cases(58.0%),SCC showed that HPV-positive was 8 cases (5.8%).High-risk HPV was 42 cases,and positive rate was 30.4%.Samples of different types of high-risk HPV infection had significant difference ( P<0.05).When TCT and HPV were both ( -),there had no high grade lesion .When HPV-positive and TCT abnormal both oc-curred,detection rate of ≥CINⅠwas 34.8%.When TCT was abnormal HPV (-),the detection rate was 47.8%.Conclusion High-risk HPV genotyping assay combined with liquid-based cervical cytology is a valuable method for early screening of cervical cancer,the result is more reliable than single inspection .