CAJ | 학술논문

目的：探讨白细胞介素-24（IL-24）、血管内皮生长因子（VEGF）的表达对胶质瘤恶性程度的判断价值。方法采用免疫组织化学SABC 法检测40例胶质细胞瘤标本和40例非瘤脑组织中IL-24、VEGF 蛋白的表达。结果高级别胶质瘤、低级别胶质瘤及非瘤脑组织的肿瘤微血管密度（ MVD）之间比较，差异均有统计学意义（ P＜0．05）。 IL-24表达与病理组织学分级呈显著负相关（γ＝-0．416，P＜0．05）。 VEGF 表达与胶质细胞瘤病理组织学的分级呈显著正相关（γ＝0．524，P＜0．05）。 IL-24和 VEGF 阳性表达与阴性表达的 MVD 之间比较，差异均有统计学意义（P＜0．05）。结论 IL-24、VEGF 与肿瘤血管生成之间具有良好相关性，其表达水平可作为判断胶质细胞瘤恶性程度的重要生物学指标。
목적：탐토백세포개소-24（IL-24）、혈관내피생장인자（VEGF）적표체대효질류악성정도적판단개치。방법채용면역조직화학SABC 법검측40례효질세포류표본화40례비류뇌조직중IL-24、VEGF 단백적표체。결과고급별효질류、저급별효질류급비류뇌조직적종류미혈관밀도（ MVD）지간비교，차이균유통계학의의（ P＜0．05）。 IL-24표체여병리조직학분급정현저부상관（γ＝-0．416，P＜0．05）。 VEGF 표체여효질세포류병리조직학적분급정현저정상관（γ＝0．524，P＜0．05）。 IL-24화 VEGF 양성표체여음성표체적 MVD 지간비교，차이균유통계학의의（P＜0．05）。결론 IL-24、VEGF 여종류혈관생성지간구유량호상관성，기표체수평가작위판단효질세포류악성정도적중요생물학지표。
Objective To study the expression of interleukin-24(IL-24) and vascular endothelial growth factor (VEGF) in the diagnosis of different malignant degree of human glioma .Methods Immunohistochemical method ( SABC) was used to de-tect the level of IL-24 and VEGF in 40 cases of glioma and 40 cases of normal brain tissues .Results The microvascular density (MVD) in high grade glioma,low grade gliomas and non tumor brain tissues were significantly different (P<0.05).The expres-sion of IL-24 was negatively correlated with histologic grading (γ=-0.416,P<0.05),and VEGF was positively correlated with histologic grading(γ=0.524,P<0.05).The MVD between positive and negative expression of IL-24 and VEGF were statistical-ly different (P<0.05).Conclusion IL-24 and VEGF have close correlation with tumor angiogenesis ,and its expression can be used to judge the malignant degree of glioma .