CAJ | 학술논문

目的：系统评价英夫利昔（IFX）对克罗恩病（CD）短期、长期黏膜愈合的疗效。方法检索Pubmed、Cochrane、Embase数据库2014年1月以前公开发表的IFX与其他药物比较的随机对照试验（RCT）。按Cochrane协作网推荐的方法对文献进行质量评价并应用RevMan5.2软件进行Meta分析，评价结果的敏感性。结果符合纳入标准的英文文献4篇，共391例。合并分析结果显示：IFX对CD的短期黏膜愈合率[RR=9.45，95%CI（1.88，47.52），P=0.006]和长期黏膜愈合率[RR=2.44，95%CI（1.19，5.02），P=0.01]均明显高于对照组，差异有统计学意义。结论 IFX对CD能有效地诱导及维持黏膜愈合。
목적：계통평개영부리석（IFX）대극라은병（CD）단기、장기점막유합적료효。방법검색Pubmed、Cochrane、Embase수거고2014년1월이전공개발표적IFX여기타약물비교적수궤대조시험（RCT）。안Cochrane협작망추천적방법대문헌진행질량평개병응용RevMan5.2연건진행Meta분석，평개결과적민감성。결과부합납입표준적영문문헌4편，공391례。합병분석결과현시：IFX대CD적단기점막유합솔[RR=9.45，95%CI（1.88，47.52），P=0.006]화장기점막유합솔[RR=2.44，95%CI（1.19，5.02），P=0.01]균명현고우대조조，차이유통계학의의。결론 IFX대CD능유효지유도급유지점막유합。
Objective To assess the short-term and long-term effect of Infliximab (IFX) on the mucosal healing in the treatment of Crohn's disease. Methods Information up to Jan 2014 were retrieved from PubMed,Cochrane Library,and Em-base. Collected publications were all about randomized controlled trials (RCTs) on IFX with other drugs. Evaluated the quality of the included studies,and performed Meta-analysis by using RevMan5.2 software. Results 4 English documents with a sample size of 391 patients met the inclusion criteria,the meta-analysis showed that:the rate of short-term mucosal healing (RR 9.45,95%CI 1.88 to 47.52,P=0.006) and the long-term mucosal healing (RR 2.44,95%CI 1.19 to 5.02,P=0.01) for CD treated with IFX were better in the treatment group than that in the control group,the difference was statistically significant. Conclu-sion IFX can effectively induce and maintain the mucosal healing for CD.