CAJ | 학술논문

目的：探讨胆管细胞性肝癌的临床特征，提高其诊断率。方法收集我院2006年8月至2012年3月于我院治疗的36例原发性胆管细胞性肝癌的临床与病理资料。结果36例患者多以上腹痛、黄疸、胆管扩张为主要临床表现，合并胆石症9例；AFP升高5例，CA19-9升高9例，CEA升高3例；手术治疗28例，其中根治性切除19例（67.8%），姑息性切除9例（32.2%）。全组病例的1、3、5年生存率分别为52.1%、33.6%及17.8%，其中根治性切除病例的1、3、5年生存率分别为83.1%、47.1%及32.7%，姑息性手术切除组1、3、5年生存率分别为30.7%、7.1%及0%，行介入治疗组1、3、5年生存率分别为25.0%、0%及0%。结论胆管细胞性肝癌是原发性肝癌的一种特殊类型，掌握其临床及组织病理学特征，将有助于提高胆管细胞性肝癌与肝细胞性肝癌的鉴别诊断水平。
목적：탐토담관세포성간암적림상특정，제고기진단솔。방법수집아원2006년8월지2012년3월우아원치료적36례원발성담관세포성간암적림상여병리자료。결과36례환자다이상복통、황달、담관확장위주요림상표현，합병담석증9례；AFP승고5례，CA19-9승고9례，CEA승고3례；수술치료28례，기중근치성절제19례（67.8%），고식성절제9례（32.2%）。전조병례적1、3、5년생존솔분별위52.1%、33.6%급17.8%，기중근치성절제병례적1、3、5년생존솔분별위83.1%、47.1%급32.7%，고식성수술절제조1、3、5년생존솔분별위30.7%、7.1%급0%，행개입치료조1、3、5년생존솔분별위25.0%、0%급0%。결론담관세포성간암시원발성간암적일충특수류형，장악기림상급조직병이학특정，장유조우제고담관세포성간암여간세포성간암적감별진단수평。
Objective To improve the surgical treatment in patients with primary cholangiocarcinoma.Methods The clinical and pathological features were analyzed in 36 patients with primary cholangiocarcinoma retrospectively.Results The main symptoms were epigastric pain, jaundice and cholangiectasis dilatation. AFP elevated in 5 out of 36 patients, CA19-9 elevated in 9 out of 36 patients, CEA elevated in 3 out of 36 patients.Hepatectomy was performed in 28 patients.19 underwent radical resection and 9 paliative resection, In the radical resection group, the 1,3 and 5 year survival rates were 83.1%, 47.1% and 32.7%; In the paliative resection group, the 1, 3 and 5 year survival rates were 30.7%, 7.1%, 0%; In the interventional therapy group, the 1, 3 and 5 year survival rates were 25.0%, 0%, 0%.Conclusion Early diagnosis and treatment provide better survival opportunity for patients with primary cholangiocarcinoma.