CAJ | 학술논문

目的：探讨全身神经内分泌肿瘤（NET）的好发部位、临床症状、影像学及预后。方法回顾性分析南方医院2001年1月至2012年4月222例NET患者的病历资料。结果222例NET患者中，152例（68.5%）NET发生在消化道。突触素（Syn）、嗜铬素A（CgA）、神经元特异性烯醇化酶（NSE）免疫组织化阳性率分别为85.1%、64.2%、81.9%。首诊淋巴结转移率为23.9%，随访结束时远处转移率为30.6%；淋巴转移和远处器官转移随肿瘤直径增加而升高。193例接受手术治疗（108例内镜下治疗），1年、3年、5年总生存率分别为86.1%、73.0%和70.9%。年龄>50岁发生转移者生存时间明显缩短。结论 NET可发生于全身许多器官和组织，以消化道最为多见，肿瘤直径与转移密切相关，患者年龄及肿瘤转移与预后有关。
목적：탐토전신신경내분비종류（NET）적호발부위、림상증상、영상학급예후。방법회고성분석남방의원2001년1월지2012년4월222례NET환자적병력자료。결과222례NET환자중，152례（68.5%）NET발생재소화도。돌촉소（Syn）、기락소A（CgA）、신경원특이성희순화매（NSE）면역조직화양성솔분별위85.1%、64.2%、81.9%。수진림파결전이솔위23.9%，수방결속시원처전이솔위30.6%；림파전이화원처기관전이수종류직경증가이승고。193례접수수술치료（108례내경하치료），1년、3년、5년총생존솔분별위86.1%、73.0%화70.9%。년령>50세발생전이자생존시간명현축단。결론 NET가발생우전신허다기관화조직，이소화도최위다견，종류직경여전이밀절상관，환자년령급종류전이여예후유관。
Objective The aim of this study was to explore the occurrence site, clinical manifestations, imaging characteristics, and prognosis of neuroendocrine tumor (NET). Methods From Jan. 2001 to Apr. 2012, medical records of 222 NET patients which were confirmed by pathology in Nanfang Hospital were ana-lyzed retrospectively. Results Of the 222 NET cases, 152 cases (68.5%) of NET were located in gastrointesti-nal tract. The positive rates of synaptophysin (Syn), chromogranin A (CgA), and neuron specific enolase (NSE) were 85.1%, 64.2%, and 81.9%, respectively. Lymphatic metastases were found in 53 cases (23.9%) at the first visit, and distant metastases in 68 cases (30.6%) at last follow-up. The lymph node metastasis and distant metastasis elevated with the increasing tumor diameter. Surgery, including 108 cases of endoscopic treatment, was performed in 193 cases. The 1-, 3-, 5-year total survival rates were 86.1%, 73.0%, 70.9%, respectively. Age>50 years, lymphatic and distant metastasis contributed to unfavorable prognosis, while gender had no ef-fect on overall survival. Conclusion NET may occur at many organs and tissues, but most of the NET occurs in the gastrointestinal tract. Endoscopy and imaging examination play an important role in diagnosis, but final diagnosis is mainly based on pathological diagnosis. Surgery is the major treatment option. The diameter of NET is closely related to metastasis. The prognosis of NET is correlated with age and metastasis.