CAJ | 학술논문

目的：探讨具有上消化道症状病人幽门螺杆菌（Helicobacter pylori, H. pylori）感染状况及家庭聚集性。方法对具有上消化道症状而来我院消化科门诊就诊的病人8750人，进行14C-尿素呼气试验（14C-urea breath test,14C-UBT）检测H. pylori感染，以及对上述病人进行宣教，动员其家庭成员自愿参加该检测项目，其中资料完整的有840个家庭，共2905人，确定是否存在H. pylori感染，且问卷登记其家庭环境因素如家庭收入和教育状况等。结果8570例具有上消化道症状病人中H. pylori总感染率为61.29%，不同年龄组H. pylori感染率不同（χ2=224.672，P<0.001），且有典型随年龄增长而上升的趋势，但性别间差异无统计学意义（χ2=0.346，P=0.556）。通过二项分布拟合优度检验探讨H. pylori感染的家庭聚集性，H. pylori感染在家庭内的分布不符合二项分布[字2=22.05，字2（0.05，3）=7.81，P<0.05不符合二项分布]，在理论分布上发现H. pylori感染有家庭聚集性分布趋势，夫妻之间H. pylori感染率情况一致（P=0.494，P>0.05），夫妻H. pylori感染的符合率为56.90%。双亲感染家庭儿童的H. pylori感染率为51%高于双亲未感染家庭儿童的H. pylori感染率为29%（χ2=27.102，P<0.001）。环境因素良好家庭儿童感染的比例（32%）明显低于环境因素一般（49%）及环境因素较差（56%）的两种家庭（χ2=33.543，P<0.001）。结论具有上消化道症状的门诊病人H. pylori感染率较高，性别间差异不明显，家庭成员内H. pylori感染具有聚集性，环境因素与儿童感染H. pylori呈负相关。
목적：탐토구유상소화도증상병인유문라간균（Helicobacter pylori, H. pylori）감염상황급가정취집성。방법대구유상소화도증상이래아원소화과문진취진적병인8750인，진행14C-뇨소호기시험（14C-urea breath test,14C-UBT）검측H. pylori감염，이급대상술병인진행선교，동원기가정성원자원삼가해검측항목，기중자료완정적유840개가정，공2905인，학정시부존재H. pylori감염，차문권등기기가정배경인소여가정수입화교육상황등。결과8570례구유상소화도증상병인중H. pylori총감염솔위61.29%，불동년령조H. pylori감염솔불동（χ2=224.672，P<0.001），차유전형수년령증장이상승적추세，단성별간차이무통계학의의（χ2=0.346，P=0.556）。통과이항분포의합우도검험탐토H. pylori감염적가정취집성，H. pylori감염재가정내적분포불부합이항분포[자2=22.05，자2（0.05，3）=7.81，P<0.05불부합이항분포]，재이론분포상발현H. pylori감염유가정취집성분포추세，부처지간H. pylori감염솔정황일치（P=0.494，P>0.05），부처H. pylori감염적부합솔위56.90%。쌍친감염가정인동적H. pylori감염솔위51%고우쌍친미감염가정인동적H. pylori감염솔위29%（χ2=27.102，P<0.001）。배경인소량호가정인동감염적비례（32%）명현저우배경인소일반（49%）급배경인소교차（56%）적량충가정（χ2=33.543，P<0.001）。결론구유상소화도증상적문진병인H. pylori감염솔교고，성별간차이불명현，가정성원내H. pylori감염구유취집성，배경인소여인동감염H. pylori정부상관。
Objective To explore Helicobacter pylori (H. pylori) infection status and its familial cluster-ing tendency in patients with upper gastrointestinal symptom. Methods Eight thousand seven hundred and fifty outpatients with upper gastrointestinal symptom were enrolled. Patients and their family members under-went a 14C-urea breath test for H. pylori infection status. There were 840 families and 2,905 subjects who par-ticipated in this study. Participants were asked to fill up a questionnaire on life environment factors such as family income and education status, etc. Result The total H. pylori infection rate was 61.29%in 8,750 outpa-tients with upper gastrointestinal symptom. H. pylori infection rate was different in different age groups (χ2=224.672, P<0.001). There was no significant difference between male and female (χ2=0.346, P=0.556). To find out whether H. pylori could infect among family members, binomial distribution test was employed. The results showed that the data did not follow binomial distribution. In theoretical distribution, it was found that H. pylori infection tended to cluster in families. Concurrent infection rate of H. pylori between husband and wife was 56.90%. If parents were H. pylori infected, their children had 51%to be infected by H. pylori, which was much higher than children whose parents did not get H. pylori infection (29%)(χ2=27.102, P<0.001). The proportion of children infected by H. pylori in a better environment (32%) was obviously lower than children in normal (49%) and poor environment (56%). Conclusion Outpatients with upper gastrointestinal symptom has higher incidence of H. pylori infection. Infection among family members may cause family clustering, while the environment is negative correlation on H. pylori infection in children.