CAJ | 학술논문

绝经后骨质疏松症主要是由于卵巢功能的减退或衰竭、雌激素水平下降而导致破骨细胞的骨吸收大于成骨细胞的骨形成，以进行性骨丢失、骨小梁退行性病变、骨质疏松、骨脆性增加和骨折风险增加为临床特征的全身性疾病，具有发病率随绝经年限延长而增高的特点。临床中相当数量的绝经后女性并不重视骨质疏松的严重性，从而延误了预防和治疗的最佳时机，增加了骨质疏松症治疗的复杂性。激素替代治疗是预防和治疗绝经后女性骨质疏松的有效方法之一，尤其是对于预防过早绝经妇女的骨质丢失已成为一线的治疗手段，且具有成本低、安全性高的优点。激素替代治疗不仅可增加患者的骨密度、减缓骨丢失，而且还可使血清降钙素、碱性磷酸酶骨质破坏的标志物较基础水平明显下降，起到预防和治疗绝经后妇女骨质疏松和骨折的作用。本文就绝经后妇女骨质的改变进行综述。
절경후골질소송증주요시유우란소공능적감퇴혹쇠갈、자격소수평하강이도치파골세포적골흡수대우성골세포적골형성，이진행성골주실、골소량퇴행성병변、골질소송、골취성증가화골절풍험증가위림상특정적전신성질병，구유발병솔수절경년한연장이증고적특점。림상중상당수량적절경후녀성병불중시골질소송적엄중성，종이연오료예방화치료적최가시궤，증가료골질소송증치료적복잡성。격소체대치료시예방화치료절경후녀성골질소송적유효방법지일，우기시대우예방과조절경부녀적골질주실이성위일선적치료수단，차구유성본저、안전성고적우점。격소체대치료불부가증가환자적골밀도、감완골주실，이차환가사혈청강개소、감성린산매골질파배적표지물교기출수평명현하강，기도예방화치료절경후부녀골질소송화골절적작용。본문취절경후부녀골질적개변진행종술。
Postmenopausal osteoporosis is mainly due to the loss of ovarian function or failure, decreased estrogen levels caused by broken bone resorption of bone cells than of osteoblasts in bone formation, with progressive bone loss, bone trabecular degenerative diseases, osteoporosis, increased osteopsathyrosis and increased risk of fracture for the clinical features of systemic disease.Numbers of clinical postmenopausal women do not attach importance to the severity of osteoporosis,which delay the best time of the prevention and treatment, increase the complexity of the osteoporosis treatment. Hormone replacement therapy for the prevention and treatment of osteoporosis in postmenopausal women is one of effective method,especially for prevention of early postmenopausal bone loss has be-come a first-line treatment,and has advantages of low cost and high security.Hormone replacement therapy can increase not only in patients with bone mineral density, slow bone loss,but also can make hints of bone destruction markers, such as the serum calcitonin and alkaline phosphatase levels decrease obviously, which play a role in prevention and treatment of postmenopausal osteoporosis and fractures.In this paper, the changes of osteoporosis in postmenopausal women is reviewed.