CAJ | 학술논문

目的：探讨硫氧还蛋白还原酶（TR）在结直肠癌中的活性表达及临床意义。方法检测30例结直肠癌患者及30例健康体检者血浆中TR活性表达，并作相关分析；对30例结直肠癌患者TR和CEA，CA19-9，CA72-4的检测结果进行回顾性分析，分析TR和CEA，CA19-9，CA72-4在结直肠癌患者中的阳性率。结果结直肠癌患者血浆中TR活性明显高于健康体检者，且有统计学意义（P＜0．05）。结直肠癌患者TR，CEA，CA19-9， CA72-4的阳性率分别为50．00％，26．67％，43．33％，20．00％．结论TR活性表达与结直肠癌密切相关，且在结直肠癌中TR的阳性率高于CEA，CA19-9，CA72-4的阳性率，有望成为新的结直肠癌的标志物。
목적：탐토류양환단백환원매（TR）재결직장암중적활성표체급림상의의。방법검측30례결직장암환자급30례건강체검자혈장중TR활성표체，병작상관분석；대30례결직장암환자TR화CEA，CA19-9，CA72-4적검측결과진행회고성분석，분석TR화CEA，CA19-9，CA72-4재결직장암환자중적양성솔。결과결직장암환자혈장중TR활성명현고우건강체검자，차유통계학의의（P＜0．05）。결직장암환자TR，CEA，CA19-9， CA72-4적양성솔분별위50．00％，26．67％，43．33％，20．00％．결론TR활성표체여결직장암밀절상관，차재결직장암중TR적양성솔고우CEA，CA19-9，CA72-4적양성솔，유망성위신적결직장암적표지물。
Objective To explore the expression of thioredoxin reductase activity in colorectal cancer and its clinical signifi -cance.Methods Thirty cases of colorectal cancer patients and 30 healthy subjects were chosen for detecting serum TR activity expression and carrying out correlation analysis .The positive rates of serum TR and CEA ,CA19-9,CA72-4 from 30 colorectal cancer patients were ana-lyzed.Results TR activity in serum of patients with colorectal cancer was significantly higher than healthy subjects ,and there was statistical-ly significant(P<0.05).The positive rates of TR and CEA,CA19-9,CA72-4 in colorectal cancer were 50.00%and 26.67%,43.33%,20. 00%.Conclusion The expression of TR activity expression is closely related to colorectal cancer ,and the TR in colorectal cancer is higher than CEA,CA19-9,CA72-4 positive rate.It is expected to become a new marker of colorectal cancer .