潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2014年
1期
45-47
,共3页
重型乙型肝炎,慢性%TNF-α%IL-10
重型乙型肝炎,慢性%TNF-α%IL-10
중형을형간염,만성%TNF-α%IL-10
Chronic severe hepatitis B%Tumor necrosis factor alpha%Interleukin 10
目的：探讨慢性重型乙型肝炎患者血清肿瘤坏死因子-α（TNF-α）、白介素-10（IL-10）水平的变化及临床意义。方法采用酶联免疫吸附法（ELISA）测定30例慢性重型乙型肝炎（CSHB）患者、30例慢性乙型肝炎（CHB）患者血清TNF-α，IL-10水平，全自动生化分析仪检测肝功能，全自动血凝仪测定凝血酶原活动度（PTA）。结果CSHB组TNF-α（119．73±18．01）ng/L显著高于CHB组（59．86±15．09）ng/L（P＜0．05），IL-10（58．44±11．86）ng/L高于CHB组（40．33±13．89）ng/L（P＞0．05）。 CSHB组TNF-α，IL-10水平与丙氨酸氨基转移酶（ALT）无明显相关性，与总胆红素（TBil）呈显著正相关，与凝血酶原活动度（PTA）呈负相关。结论TNF-α，IL-10参与了慢性重型乙型肝炎的肝损伤过程，可能参与了重型肝炎的发病机制，可作为评估病情的观察指标。
目的：探討慢性重型乙型肝炎患者血清腫瘤壞死因子-α（TNF-α）、白介素-10（IL-10）水平的變化及臨床意義。方法採用酶聯免疫吸附法（ELISA）測定30例慢性重型乙型肝炎（CSHB）患者、30例慢性乙型肝炎（CHB）患者血清TNF-α，IL-10水平，全自動生化分析儀檢測肝功能，全自動血凝儀測定凝血酶原活動度（PTA）。結果CSHB組TNF-α（119．73±18．01）ng/L顯著高于CHB組（59．86±15．09）ng/L（P＜0．05），IL-10（58．44±11．86）ng/L高于CHB組（40．33±13．89）ng/L（P＞0．05）。 CSHB組TNF-α，IL-10水平與丙氨痠氨基轉移酶（ALT）無明顯相關性，與總膽紅素（TBil）呈顯著正相關，與凝血酶原活動度（PTA）呈負相關。結論TNF-α，IL-10參與瞭慢性重型乙型肝炎的肝損傷過程，可能參與瞭重型肝炎的髮病機製，可作為評估病情的觀察指標。
목적：탐토만성중형을형간염환자혈청종류배사인자-α（TNF-α）、백개소-10（IL-10）수평적변화급림상의의。방법채용매련면역흡부법（ELISA）측정30례만성중형을형간염（CSHB）환자、30례만성을형간염（CHB）환자혈청TNF-α，IL-10수평，전자동생화분석의검측간공능，전자동혈응의측정응혈매원활동도（PTA）。결과CSHB조TNF-α（119．73±18．01）ng/L현저고우CHB조（59．86±15．09）ng/L（P＜0．05），IL-10（58．44±11．86）ng/L고우CHB조（40．33±13．89）ng/L（P＞0．05）。 CSHB조TNF-α，IL-10수평여병안산안기전이매（ALT）무명현상관성，여총담홍소（TBil）정현저정상관，여응혈매원활동도（PTA）정부상관。결론TNF-α，IL-10삼여료만성중형을형간염적간손상과정，가능삼여료중형간염적발병궤제，가작위평고병정적관찰지표。
Objective To investigate the change of serum tumor necrosis factor alpha (TNF-α) and interleu-kin 10(IL-10) in chronic severe hepatitis B(CSHB) and its clinical significance.Methods Thirty patients with chronic severe hepatitis B(CSHB) and 30 chronic hepatitis B patients were determined for the levels of serum TNF-αand IL-10 by enzyme-linked immunosorbent (ELISA),automatic biochemical analyzer test liver function ,blood coagulation instru-ment automatic measuring prothrombin activity (PTA).Results The serum levels of TNF-αand IL-10 in patients with CSHB were (119.73 ±18.01)ng/L and (58.44 ±11.86)ng/L,and the TNF-αlevels were significantly higher than that in CHB patients (P<0.05),and the IL-10 levels were higher than that in CHB patients (P>0.05).In CSHB group,the serum levels of TNF-αand IL-10 were presented to be a positive correlation with total bilirubin (TBil),and negative correlation with prothrombin activity (PTA).However,there was no correlation with serum alanine aminotrans-ferase(ALT).There was no correlation between the serum TNF-αlevels and the serum IL-10 levels.Conclusion TNF-α,IL-10 participated in the liver damage process of chronic severe hepatitis B ,may be involved in the pathogenesis of se-vere hepatitis,observation of can be used as evaluating indicator on disease status .
