CAJ | 학술논문

目的：探讨慢性乙型肝炎（CHB）和乙肝后肝硬化（LC）患者血清胆碱酯酶（ChE）与肝纤维化标志物透明质酸（HA）、层粘连蛋白（LN）、Ⅳ型胶原（Ⅳ? C）、Ⅲ型前胶原（PCⅢ）的相关性。方法用CX5型全自动生化分析仪测定143例CHB和134例LC患者血清ChE水平，用放射免疫法（RIA）测定HA，LN，Ⅳ? C，PCⅢ水平，并与92例健康体检者比较。结果CHB轻度、中度、重度和LC A级、B级、C级患者，随病情进展，血清ChE活性依次降低；肝纤维化指标HA，LN，Ⅳ? C，PCⅢ水平逐渐升高，变化趋势的差异具有显著性（P＜0．05）；血清ChE活性与HA，LN，Ⅳ? C，PCⅢ水平呈显著负相关。结论血清ChE和HA，LN，Ⅳ? C，PCⅢ水平是反映肝纤维化程度的敏感指标，对该疾病的早期诊断、治疗及预后判断有重要的临床应用价值。
목적：탐토만성을형간염（CHB）화을간후간경화（LC）환자혈청담감지매（ChE）여간섬유화표지물투명질산（HA）、층점련단백（LN）、Ⅳ형효원（Ⅳ? C）、Ⅲ형전효원（PCⅢ）적상관성。방법용CX5형전자동생화분석의측정143례CHB화134례LC환자혈청ChE수평，용방사면역법（RIA）측정HA，LN，Ⅳ? C，PCⅢ수평，병여92례건강체검자비교。결과CHB경도、중도、중도화LC A급、B급、C급환자，수병정진전，혈청ChE활성의차강저；간섬유화지표HA，LN，Ⅳ? C，PCⅢ수평축점승고，변화추세적차이구유현저성（P＜0．05）；혈청ChE활성여HA，LN，Ⅳ? C，PCⅢ수평정현저부상관。결론혈청ChE화HA，LN，Ⅳ? C，PCⅢ수평시반영간섬유화정도적민감지표，대해질병적조기진단、치료급예후판단유중요적림상응용개치。
Objective To explore the correlation between serum cholinesterase (ChE) of chronic hepatitis (CHB) and liver cirrhosis(LC) patients and liver fibrosis markers,such as hyaluronic acid(HA),laminin(LN),colla-gen typeⅣ(Ⅳ? C),procollagen typeⅢ(PCⅢ).Methods The serum ChE was assayed by CX5 automatic biochemi-cal in 143 cases of CHB and 134 cases of LC;the serum HA,LN,Ⅳ? C,PCⅢ were assayed by radioimmunoassay (RIA).Then detection results of these markers were compared with those from 50 healthy people.Results Among pa-tients with CHB graded mild,moderate,severe and LC graded,A B C,the serum ChE activity gradually decreased ,with the progress of the disease,but hepatic fibrosis indexes of HA ,LN,Ⅳ? C,PCⅢlevel gradually increased.It showed the statistical difference(P<0.01).The change trend was negatively correlated between the serum ChE activity and HA , LN,Ⅳ? C,PCⅢlevel.Conclusion The change of serum ChE and HA,LN,Ⅳ? C,PCⅢlevel is a sensitive markers to reflect the degree of hepatic fibrosis.It shows great value of clinical application for the disease early diagnosis ,treat-ment and prognosis.