CAJ | 학술논문

目的：探讨血清学筛查在高龄孕妇产前诊断中的应用价值。方法回顾性分析2012年1月1日-2012年10月31日行胎儿染色体核型分析的高龄孕妇314例，按预产期年龄分为35～39岁组和≥40岁组；按血清学筛查情况分为血清学筛查低危组、血清学筛查高危组和未做血清学筛查组，分析各组胎儿染色体异常率。结果胎儿染色体异常率4．14％（13/314）。≥40岁组胎儿染色体异常率13．21％（7/53），高于35～39岁组2．30％（6/261）（ P＝0．001）。血清学筛查高危组胎儿染色体异常率7．69％（7/91），高于血清学筛查低危组0（0/64）（ P＝0．022）。结论对高龄孕妇进行血清学筛查，有助于减少介入性产前诊断率。
목적：탐토혈청학사사재고령잉부산전진단중적응용개치。방법회고성분석2012년1월1일-2012년10월31일행태인염색체핵형분석적고령잉부314례，안예산기년령분위35～39세조화≥40세조；안혈청학사사정황분위혈청학사사저위조、혈청학사사고위조화미주혈청학사사조，분석각조태인염색체이상솔。결과태인염색체이상솔4．14％（13/314）。≥40세조태인염색체이상솔13．21％（7/53），고우35～39세조2．30％（6/261）（ P＝0．001）。혈청학사사고위조태인염색체이상솔7．69％（7/91），고우혈청학사사저위조0（0/64）（ P＝0．022）。결론대고령잉부진행혈청학사사，유조우감소개입성산전진단솔。
Objective To investigate the incidence of chromosome abnormalities in advanced maternalage(AMA) ,and to investigate the value of prenatal screening in AMA . Methods Retrospective analysis of 314 cases of AMA which had invasive prenatal diagnosis .314 cases of AMA were divided into two groups according to expected date of childbirth age :35~39 years old and older than 40 years old . And they were also divided into three groups according to serum screening :low-risk serum screening group ,high-risk serum screening and without serum screeningand ,to analyze the percentage of fetal chro-mosome abnormalities in these groups . Results The percentage of fetal chromosomal abnormalities of 314 AMA was 4 .14% (13/314) . The percentage of fetal chromosomal abnormalities in AMA whose ma-ternal age older than 40 years old was 13 .21% (7/53) ,which was higher than that in AMA whose mater-nal age 35~39 years old 2 .30% (6/261) (P=0 .001) . In high-risk serum screening group ,the percent-age of fetal chromosome abnormalities was 7 .69% (7/91) ,which was higher than that in low-risk serum screening group 0 (0/64) (P=0 .022) . Conclusions Maternal prenatal screening tests could be applied in AMA .