甘肃农业大学学报
甘肅農業大學學報
감숙농업대학학보
JOURNAL OF GANSU AGRICULTURAL UNIVERSITY
2014年
5期
33-36
,共4页
葛根素%去卵巢大鼠%对氧磷酶 1%血脂%雌激素
葛根素%去卵巢大鼠%對氧燐酶 1%血脂%雌激素
갈근소%거란소대서%대양린매 1%혈지%자격소
puerarin%ovariectomized rat%paraoxonase 1%blood lipids%estrogen
为了探讨葛根素对去卵巢大鼠血清中对氧磷酶1(PON1)活性及血脂的影响,将48只雌性大鼠随机分为6组,设阴性对照组,即假手术对照组(SHAM)；阳性对照组,即去卵巢对照组(OVX)；雌激素治疗组(OE)及不同剂量葛根处理组,OPl 20 mg/(kg·d)、OPm 50 mg/(kg·d)、OPh 100 mg/(kg·d).8周后测定所有处理大鼠血清PON1活性、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)和胆固醇(TC)水平,计算动脉粥样硬化指数(AI).结果发现：OVX组大鼠PON1活性比假手术组(SHAM)降低,葛根素组和雌激素组的PON1活性比 OVX组高,与 SHAM组相似.OVX组 HDL-C降低,LDL-C升高,葛根素组和雌激素组的 HDL-C升高,LDL-C降低.多元线性回归分析发现,雌激素水平与 PON1活性呈线性正相关(r=0.294,P=0.043).据此认为,葛根素可提高去卵巢大鼠PON1活性,降低动脉粥样硬化的易患性,可能有预防妇女绝经后心血管疾病发生的作用.
為瞭探討葛根素對去卵巢大鼠血清中對氧燐酶1(PON1)活性及血脂的影響,將48隻雌性大鼠隨機分為6組,設陰性對照組,即假手術對照組(SHAM)；暘性對照組,即去卵巢對照組(OVX)；雌激素治療組(OE)及不同劑量葛根處理組,OPl 20 mg/(kg·d)、OPm 50 mg/(kg·d)、OPh 100 mg/(kg·d).8週後測定所有處理大鼠血清PON1活性、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、甘油三酯(TG)和膽固醇(TC)水平,計算動脈粥樣硬化指數(AI).結果髮現：OVX組大鼠PON1活性比假手術組(SHAM)降低,葛根素組和雌激素組的PON1活性比 OVX組高,與 SHAM組相似.OVX組 HDL-C降低,LDL-C升高,葛根素組和雌激素組的 HDL-C升高,LDL-C降低.多元線性迴歸分析髮現,雌激素水平與 PON1活性呈線性正相關(r=0.294,P=0.043).據此認為,葛根素可提高去卵巢大鼠PON1活性,降低動脈粥樣硬化的易患性,可能有預防婦女絕經後心血管疾病髮生的作用.
위료탐토갈근소대거란소대서혈청중대양린매1(PON1)활성급혈지적영향,장48지자성대서수궤분위6조,설음성대조조,즉가수술대조조(SHAM)；양성대조조,즉거란소대조조(OVX)；자격소치료조(OE)급불동제량갈근처리조,OPl 20 mg/(kg·d)、OPm 50 mg/(kg·d)、OPh 100 mg/(kg·d).8주후측정소유처리대서혈청PON1활성、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、감유삼지(TG)화담고순(TC)수평,계산동맥죽양경화지수(AI).결과발현：OVX조대서PON1활성비가수술조(SHAM)강저,갈근소조화자격소조적PON1활성비 OVX조고,여 SHAM조상사.OVX조 HDL-C강저,LDL-C승고,갈근소조화자격소조적 HDL-C승고,LDL-C강저.다원선성회귀분석발현,자격소수평여 PON1활성정선성정상관(r=0.294,P=0.043).거차인위,갈근소가제고거란소대서PON1활성,강저동맥죽양경화적역환성,가능유예방부녀절경후심혈관질병발생적작용.
In order to investigate the effects of puerarin on paraoxonase1 and blood lipids in ovariecto-mized (OVX)rats,a total of 48 female SD rats were divided randomly into sham operated (SHAM),OVX, 1 7β-estradiol treated,low-dose puerarin,middle-dose puerarin and high-dose puerarin groups.The rats were sacrificed at the end of 8th week after operation.OVX resulted in reduction of PON1 activity and PON1 ac-tivity of the HDL-C was significantly increased in estrogen and high-dose puerarin treated groups compared with OVX groups.Compared with that in OVX group,HDL-C was increased respectively in OPm group and OPh group by 23.9% and 24.5%.In OPm and OPh groups,the levels of LDL-C was decreased by 69.1%and 78.2%.PON1 activity in OVX rats was lower than that in SHAM rats.It is suggested that puerarin was efficient to improve the PON1 activity and to adj ust blood lipids in OVX rats.
