CAJ | 학술논문

目的：观察蛭龙活血通瘀胶囊对COPD 并肺心病心力衰竭心功能、HS-CRP 及 BNP 的影响。方法：将60例COPD并肺心病心力衰竭患者随机分为治疗组和对照组，所有患者予以常规抗心衰治疗，治疗组加服蛭龙活血通瘀胶囊，疗程4周。治疗前后观察心功能，ELISA法和散射比浊法测定血浆N-末端脑钠肽前（NT-proBNP）、高敏C反应蛋白（HS-CRP）水平。结果：治疗组总有效率为90%，明显高于对照组总有效率73%，心功能明显好转，血浆NT-proBNP、HS-CRP水平均明显下降，（P＜0.05）。结论：蛭龙活血通瘀胶囊治疗肺心病心力衰竭效果确切，其主要作用机制为降低血浆NT-proBNP、HS-CRP水平。
목적：관찰질룡활혈통어효낭대COPD 병폐심병심력쇠갈심공능、HS-CRP 급 BNP 적영향。방법：장60례COPD병폐심병심력쇠갈환자수궤분위치료조화대조조，소유환자여이상규항심쇠치료，치료조가복질룡활혈통어효낭，료정4주。치료전후관찰심공능，ELISA법화산사비탁법측정혈장N-말단뇌납태전（NT-proBNP）、고민C반응단백（HS-CRP）수평。결과：치료조총유효솔위90%，명현고우대조조총유효솔73%，심공능명현호전，혈장NT-proBNP、HS-CRP수평균명현하강，（P＜0.05）。결론：질룡활혈통어효낭치료폐심병심력쇠갈효과학절，기주요작용궤제위강저혈장NT-proBNP、HS-CRP수평。
Objective:To observe the effect of Zhilong Huoxue Tongyu capsules on heart function, HS-CRP and BNP in patients with COPD complicated by heart failure. Methods: 60 patients with COPD complicated by heart failure were randomly divided into test group and control group,except conventional anti-heart failure treatment, the test group erceived Zhilong Huoxue Tongyu capsule 4 weeks.The heartfunction was observed before and after treatment, NT-proBNP、and HS-CRP were detected by ELISA and dispersion turbidimetry. Results:Compared with control group,the total effective rate was raised,heart function became better,and NT-proBNP and HS-CRP were significantly decreased (P<0.05). Conclusion:Zhilong Huoxue Tongyu capsule has definite effect on heart failure patients and the mechanism may lie in decreasing NT-proBNP and HS-CRP.