CAJ | 학술논문

建立了人体血液中有机磷杀虫剂及毒品类、安眠镇静类药物的气相色谱检测方法。以咖啡因、甲基苯丙胺、氯胺酮、吗啡、安定、苯巴比妥、阿普唑仑、甲拌磷、敌百虫、对硫磷为待测品，利用微珠萃取法，对搅拌提取时间、洗脱溶剂量、pH值、溶液离子强度等方面进行了优化，结果表明人血中上述三类药物的最佳提取条件为：pH值依药物酸碱性而定，搅拌提取30min，洗脱溶剂量1.0mL，回收率均超过70%，相对标准偏差低于5%，达到实际案件分析要求。
건립료인체혈액중유궤린살충제급독품류、안면진정류약물적기상색보검측방법。이가배인、갑기분병알、록알동、마배、안정、분파비타、아보서륜、갑반린、활백충、대류린위대측품，이용미주췌취법，대교반제취시간、세탈용제량、pH치、용액리자강도등방면진행료우화，결과표명인혈중상술삼류약물적최가제취조건위：pH치의약물산감성이정，교반제취30min，세탈용제량1.0mL，회수솔균초과70%，상대표준편차저우5%，체도실제안건분석요구。
Gas chromatography (GC) analysis methods for the determination of organophosphorus insecticide, religious drugs and sedative-hypnotic drugs in human blood were developed. Caffeine, methyl amphetamine, ketamine, mor-phine, tranquillizer, phenobarbital, alprazolam, thimet, dipterex and parathion were selected as the target substances to optimize the extraction conditions of Micro-ball extraction. The parameters included ionic strength,pH value,extraction time and extraction solvent amount. The results indicated that the optimized conditions were as follows:the pH value of sample solution was adjusted according to the acidity and alkalescence of the drug;the vortex mixer shocking time was thirty minutes;the desorption solvent amount was 1.0mL ethanol. The recovery ratios of various drugs were more than 70%,relative standard deviations were less than 5%. It could meet the needs of actual cases.