安徽卫生职业技术学院学报
安徽衛生職業技術學院學報
안휘위생직업기술학원학보
JOURNAL OF ANHUI HEALTH VOCATIONAL & TECHNICAL COLLEGE
2014年
1期
88-89
,共2页
甲状腺肿瘤%乳头状癌%病理诊断
甲狀腺腫瘤%乳頭狀癌%病理診斷
갑상선종류%유두상암%병리진단
Thyroid neoplasms%Papillary carcinoma%Pathological diagnosis
目的：寻找更好的标记物，用于甲状腺乳头状癌的诊断与鉴别。方法：选取PTC 78例，NGWPH 32例，蜡块均带有周围正常甲状腺组织作对照，采用CK19、34βE12、MC、Galectin-3和CD56对样本进行免疫组化染色。结果：CK19、34βE12、MC、Galectin-3和CD56在PTC中的阳性表达率分别为100.0％、93.6％、92.3％、98.7％和1.3%。而在NGWPH中的阳性表达率分别为12.5％、3.1%、37.5％、12.5％和96.9%。两组比较差异有统计学意义(P<0.05)。结论：5种抗体各有优缺点，CK19、34βE12、CD56的应用价值较高，若能再联合使用MC和Galectin-3以及仔细的图像观察，可以增加PTC诊断及与NGWPH鉴别诊断的准确性。
目的：尋找更好的標記物，用于甲狀腺乳頭狀癌的診斷與鑒彆。方法：選取PTC 78例，NGWPH 32例，蠟塊均帶有週圍正常甲狀腺組織作對照，採用CK19、34βE12、MC、Galectin-3和CD56對樣本進行免疫組化染色。結果：CK19、34βE12、MC、Galectin-3和CD56在PTC中的暘性錶達率分彆為100.0％、93.6％、92.3％、98.7％和1.3%。而在NGWPH中的暘性錶達率分彆為12.5％、3.1%、37.5％、12.5％和96.9%。兩組比較差異有統計學意義(P<0.05)。結論：5種抗體各有優缺點，CK19、34βE12、CD56的應用價值較高，若能再聯閤使用MC和Galectin-3以及仔細的圖像觀察，可以增加PTC診斷及與NGWPH鑒彆診斷的準確性。
목적：심조경호적표기물，용우갑상선유두상암적진단여감별。방법：선취PTC 78례，NGWPH 32례，사괴균대유주위정상갑상선조직작대조，채용CK19、34βE12、MC、Galectin-3화CD56대양본진행면역조화염색。결과：CK19、34βE12、MC、Galectin-3화CD56재PTC중적양성표체솔분별위100.0％、93.6％、92.3％、98.7％화1.3%。이재NGWPH중적양성표체솔분별위12.5％、3.1%、37.5％、12.5％화96.9%。량조비교차이유통계학의의(P<0.05)。결론：5충항체각유우결점，CK19、34βE12、CD56적응용개치교고，약능재연합사용MC화Galectin-3이급자세적도상관찰，가이증가PTC진단급여NGWPH감별진단적준학성。
Objective:To search for a better marker for papillary thyroid cancer diagnosis and identification.. Methods:Select PTC 78 example and NGWPH 32 cases, the wax block with the surrounding normal thyroid tissue were used as control, the use of CK19, 34βE12, MC, Galectin-3 and CD56 on the samples immunohistochemical staining. Results:CK19, 34βE12, MC, Galectin-3 and CD56 positive expression in PTC rates were 100.0%, 93.6%, 92.3%, 98.7% and 1.3%. In NGWPH the positive expression rate was 12.5%, 3.1%, 37.5%, 12.5% and 96.9%. Difference between the two groups was statistically significant (P<0.05). Conclusions:Five kinds of antibodies have their advantages and disadvantages, CK19, 34βE12, CD56 high application value, if then combined with MC and Galectin-3 as well as careful observation of the image, you can increase the PTC diagnosis and differential diagnosis accuracy with NGWPH .
