CAJ | 학술논문

目的：观察胰岛素治疗2型糖尿病合并初治肺结核的疗效和安全性。方法：2型糖尿病合并初治肺结核患者60例，随机分为两组，各30例，治疗组予甘舒霖30R早晚餐前皮下注射，对照组予格列美脲+二甲双胍口服，观察12周，比较两组患者5个时点血糖、糖化血红蛋白、低血糖反应、痰菌阴转情况和肺结核病灶X线变化。结果：低血糖发生率两组无显著性差异（P>0.05），治疗组血糖和糖化血红蛋白显著低于对照组（P<0.05），痰菌阴转率治疗组（95%）显著高于对照组（72.2%）（P<0.05），病灶吸收情况治疗组（83.3%）显著好于对照组（53.3%）（P<0.01），空洞闭合治疗组（84.6%）显著好于对照组（54.5%）（P<0.01）。结论：胰岛素治疗2型糖尿病合并初治肺结核在控制血糖、痰菌阴转率、病灶吸收及空洞闭合情况均优于口服降糖药。
목적：관찰이도소치료2형당뇨병합병초치폐결핵적료효화안전성。방법：2형당뇨병합병초치폐결핵환자60례，수궤분위량조，각30례，치료조여감서림30R조만찬전피하주사，대조조여격렬미뇨+이갑쌍고구복，관찰12주，비교량조환자5개시점혈당、당화혈홍단백、저혈당반응、담균음전정황화폐결핵병조X선변화。결과：저혈당발생솔량조무현저성차이（P>0.05），치료조혈당화당화혈홍단백현저저우대조조（P<0.05），담균음전솔치료조（95%）현저고우대조조（72.2%）（P<0.05），병조흡수정황치료조（83.3%）현저호우대조조（53.3%）（P<0.01），공동폐합치료조（84.6%）현저호우대조조（54.5%）（P<0.01）。결론：이도소치료2형당뇨병합병초치폐결핵재공제혈당、담균음전솔、병조흡수급공동폐합정황균우우구복강당약。
Objective:To observe the efficacy and safety of insulin therapy in type 2 diabetes mellitus complicated with newly-treated pulmonary tuberculosis. Methods:A total of 60 patients of type 2 diabetes mellitus complicated with newly-treated pulmonary tuberculosis were randomly divided into two groups,each 30;the treatment group was treated by Ganshulin 30R subcutaneous injection before breakfast and dinner, the control group treated by Glimepiri-de+Metformin. The blood glucose for 5 times a day, HbA1c, hypoglycemia reaction, sputum conversion and tubercu-losis focus on chest X-ray were contrasted between the two groups after 12 weeks. Results:There was no significant difference on the rate of hypoglycemia reaction between the two groups (P>0.05);but the level of blood glucose and HbA1c were significantly lower in the treatment group(P<0.05);the rate of sputum conversion was (95%) for the treat-ment group and (72.2%) for the control group, respectively, there was statistically significant difference between the two groups(P<0.05);the lung focus shrinking on chest X-ray was (83.3%) and that of the control group (53.3%) ,the treatment group was significantly better than the control group(P<0.01);the cavity closure was(84.6%) and that of the control group(54.5%) , the treatment group was significantly better than the control group(P<0.01). Conclusion:Pa-tients with type 2 diabetes mellitus complicated with newly-treated pulmonary tuberculosis treated by insulin were better than oral antidiabetic drugs in blood glucose control, the rate of sputum conversion, tuberculosis focus absorp-tion and cavity closure.