CAJ | 학술논문

目的：探讨米非司酮防治早孕人流负压吸引术后残留的有效性及安全性。方法：426例流产后妇女，B超和血β-人绒毛膜促性腺激素（HCG）确诊为人流负压吸引术后残留，随机分为两组，218例常规负压吸宫组（对照组）,208例常规负压吸宫术后当天开始口服米非司酮50mg×14d（米非司酮组），比较两组临床症状、B超和血β-HCG监测的疗效及安全性。结果：人流术后行再次刮宫术6例，其中对照组5例(2.19%)，米非司酮组1例(0.48%)，组间差异有统计学意义(P<0.01)；米非司酮治疗组用药2周后阴道流血停止时间、转经时间、血β-HCG和B超明显好于对照组，差异有统计学意义(P<0.01)。结论：应用米非司酮防治人工流产术后残留有效，术后给予米非司酮口服可预防人工流产不全。
목적：탐토미비사동방치조잉인류부압흡인술후잔류적유효성급안전성。방법：426례유산후부녀，B초화혈β-인융모막촉성선격소（HCG）학진위인류부압흡인술후잔류，수궤분위량조，218례상규부압흡궁조（대조조）,208례상규부압흡궁술후당천개시구복미비사동50mg×14d（미비사동조），비교량조림상증상、B초화혈β-HCG감측적료효급안전성。결과：인류술후행재차괄궁술6례，기중대조조5례(2.19%)，미비사동조1례(0.48%)，조간차이유통계학의의(P<0.01)；미비사동치료조용약2주후음도류혈정지시간、전경시간、혈β-HCG화B초명현호우대조조，차이유통계학의의(P<0.01)。결론：응용미비사동방치인공유산술후잔류유효，술후급여미비사동구복가예방인공유산불전。
Objective:To investigate the efficacy and safety of mifepristone treating abortive remnants of incom-plete abortion.Methods:A total of 426 women undergoing post-abortion treatment who were diagnosed as abortive remnants by ultrasound and blood of human chorionic gonadotrophin (β-HCG) were divided randomly into 2 groups:control group( n=218) with routine vacuum aspiration, mifepristone group(n=208), which took oral mifepristone 50mg/d ×14 d. The efficacy and safety of two groups were evaluated by clinical observations,ultrasonic and blood level ofβ-HCG checks.Results:There were 5 cases with incomplete abortion accepted curettage again, and 5 cases(2.19%) in control group, 1 case(0.48%) in mifepristone group(P<0.01). Conclusion:Mifepristone is effective in the treatment of incomplete abortion, which takes as a drug for prevention of incomplete abortion.