西北药学杂志
西北藥學雜誌
서북약학잡지
2014年
2期
194-196
,共3页
杨凯%韦新明%刘文娟%苟苍伟%苏凤%周希胜%康玲云%郑飞
楊凱%韋新明%劉文娟%茍蒼偉%囌鳳%週希勝%康玲雲%鄭飛
양개%위신명%류문연%구창위%소봉%주희성%강령운%정비
丹参川芎嗪注射液%冠心病%心绞痛%疗效观察
丹參川芎嗪註射液%冠心病%心絞痛%療效觀察
단삼천궁진주사액%관심병%심교통%료효관찰
Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection%coronary heart disease%angina pectoris%curative effect observation
目的:探讨丹参川芎嗪注射液治疗不稳定型心绞痛(unstable angina ,UA)的疗效及安全性。方法将137例UA患者随机分为治疗组(72例)和对照组(65例),2组均给予常规抗凝、抗血小板、调脂、控制血压和/或血糖、血管紧张素转换酶抑制剂(或血管紧张素Ⅱ受体拮抗剂)、低分子肝素钙等治疗,治疗组在常规治疗的基础上,加用丹参川芎嗪注射液10 mL,加入50~100 g · L -1葡萄糖注射液或生理盐水250~500 mL中静脉滴注,1日1次,疗程15 d。结果治疗组显效率为41.6%,有效率为50.0%,无效率为8.3%,总有效率为91.7%;对照组显效率为33.8%,有效率为40.0%,无效率为26.2%,总有效率为73.8%,2组总有效率差异有统计学意义(P<0.05)。治疗组较对照组治疗后心绞痛发作次数明显减少(1.3±1.2 vs.2.8±1.8次·d-1),心绞痛持续时间明显缩短(2.35±1.13 vs.5.28±1.98min),硝酸甘油用量明显减少(0.42±0.28 vs.0.78±0.23mg·d-1),心电图显示心肌缺血明显改善。结论在常规治疗的基础上,加用丹参川芎嗪注射液治疗UA疗效确切,使用简单,且长期应用未见明显不良反应,充分体现了丹参川芎嗪注射液治疗UA的优势。
目的:探討丹參川芎嗪註射液治療不穩定型心絞痛(unstable angina ,UA)的療效及安全性。方法將137例UA患者隨機分為治療組(72例)和對照組(65例),2組均給予常規抗凝、抗血小闆、調脂、控製血壓和/或血糖、血管緊張素轉換酶抑製劑(或血管緊張素Ⅱ受體拮抗劑)、低分子肝素鈣等治療,治療組在常規治療的基礎上,加用丹參川芎嗪註射液10 mL,加入50~100 g · L -1葡萄糖註射液或生理鹽水250~500 mL中靜脈滴註,1日1次,療程15 d。結果治療組顯效率為41.6%,有效率為50.0%,無效率為8.3%,總有效率為91.7%;對照組顯效率為33.8%,有效率為40.0%,無效率為26.2%,總有效率為73.8%,2組總有效率差異有統計學意義(P<0.05)。治療組較對照組治療後心絞痛髮作次數明顯減少(1.3±1.2 vs.2.8±1.8次·d-1),心絞痛持續時間明顯縮短(2.35±1.13 vs.5.28±1.98min),硝痠甘油用量明顯減少(0.42±0.28 vs.0.78±0.23mg·d-1),心電圖顯示心肌缺血明顯改善。結論在常規治療的基礎上,加用丹參川芎嗪註射液治療UA療效確切,使用簡單,且長期應用未見明顯不良反應,充分體現瞭丹參川芎嗪註射液治療UA的優勢。
목적:탐토단삼천궁진주사액치료불은정형심교통(unstable angina ,UA)적료효급안전성。방법장137례UA환자수궤분위치료조(72례)화대조조(65례),2조균급여상규항응、항혈소판、조지、공제혈압화/혹혈당、혈관긴장소전환매억제제(혹혈관긴장소Ⅱ수체길항제)、저분자간소개등치료,치료조재상규치료적기출상,가용단삼천궁진주사액10 mL,가입50~100 g · L -1포도당주사액혹생리염수250~500 mL중정맥적주,1일1차,료정15 d。결과치료조현효솔위41.6%,유효솔위50.0%,무효솔위8.3%,총유효솔위91.7%;대조조현효솔위33.8%,유효솔위40.0%,무효솔위26.2%,총유효솔위73.8%,2조총유효솔차이유통계학의의(P<0.05)。치료조교대조조치료후심교통발작차수명현감소(1.3±1.2 vs.2.8±1.8차·d-1),심교통지속시간명현축단(2.35±1.13 vs.5.28±1.98min),초산감유용량명현감소(0.42±0.28 vs.0.78±0.23mg·d-1),심전도현시심기결혈명현개선。결론재상규치료적기출상,가용단삼천궁진주사액치료UA료효학절,사용간단,차장기응용미견명현불량반응,충분체현료단삼천궁진주사액치료UA적우세。
Objective To investigate the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in the treatment of unstable angina pectoris (unstable angina ,UA) in the term of efficacy and safety .Methods 137 cases of UA patients were ran-domly divided into treatment group(72 cases) and control group(65 cases) .The two groups were given conventional anticoagula-tion ,antiplatelet ,lipid ,blood pressure control and/or glucose ,ACEI (or ARBⅡ) ,low molecular weight heparin calcium treatment . The treatment group was treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection 10 mL in 5-100 g · L -1 glu-cose injection or saline for 250-500 mL intravenous drip on the basis of conventional therapy ,once a day ,the course of treatment was 15 d .Results The efficiency of the treatment group was 41.6% ,effective rate was 50% ,no efficiency was 8.3% ,the total ef-fective rate was 91.7% ;the efficiency of the control group was 33 .8% ,efficiency was 40% ,no efficiency was 26 .2% ,the total ef-fective rate was 73 .8% ,the total efficiency of the two groups had significant difference (P<0 .05) .In the treatment group angina was significantly reduced (1 .3 ± 1 .2 vs .2 .8 ± 1 .8 ,once a day ) ,angina duration shortened significantly (2 .35 ± 1 .13 vs .5 .28 ± 1 . 98 min) ,the dosage of nitroglycerin was significantly reduced (0 .42 ± 0 .28 vs .0 .78 ± 0 .23 mg · d-1 ) ,and ECG showed myocardi-al ischemia significantly improved .Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection shows advantages in the treatment of UA .