CAJ | 학술논문

目的：制备盐酸替扎尼定口腔黏附片并评价其质量。方法采用不同配比的羟丙甲基纤维素（H PM C ）、羧甲基纤维素钠（SCMC）、β-环糊精和羟丙基-β-环糊精等辅料，用直接压片法压片制备盐酸替扎尼定口腔黏附片，并对黏附片的理化性质、药物含量、药物体外释放度和黏附力进行评价。结果得到各项指标均较适宜的处方：盐酸替扎尼定4．56 mg ，羟丙甲纤维素20 mg ，羧甲基纤维素钠75mg，羟丙基-β-环糊精27．36mg，甘露醇4mg，阿斯巴甜1mg，微粉硅胶1mg。结论成功制备了盐酸替扎尼定口腔黏附片，可用于进一步的体内、体外研究。
목적：제비염산체찰니정구강점부편병평개기질량。방법채용불동배비적간병갑기섬유소（H PM C ）、최갑기섬유소납（SCMC）、β-배호정화간병기-β-배호정등보료，용직접압편법압편제비염산체찰니정구강점부편，병대점부편적이화성질、약물함량、약물체외석방도화점부력진행평개。결과득도각항지표균교괄의적처방：염산체찰니정4．56 mg ，간병갑섬유소20 mg ，최갑기섬유소납75mg，간병기-β-배호정27．36mg，감로순4mg，아사파첨1mg，미분규효1mg。결론성공제비료염산체찰니정구강점부편，가용우진일보적체내、체외연구。
Objective To prepare and evaluate a buccal adhesive tablet containing tiazanidine hydrochloride .Methods The tablets were prepared by using hydroxypropyl methyl cellulose (HPMC ) ,sodium carboxymethylcellulose (SCMC ) ,β-cyclodextrin , hydroxypropyl-β-cyclodextrin ,etc as the auxiliary materials .Direct compression process was used to prepare the buccal adhesive tablets ,and different parameters such as physicochemical property ,drug content ,in vitro drug release ,and mucoadhesive strength were evaluated .Results The prescription was as follows :tiazanidine hydrochloride 4 .56 mg ,hydroxypropyl methyl cellulose 20 mg ,sodium carboxymethylcellulose 75 mg ,hydroxypropyl-β-cyclodextrin 27 .36 mg ,mannitol 4 mg ,aspartame 1 mg and aerosil 1 mg .Conclusion The buccal adhesive tablets of tiazanidine hydrochloride were prepared successfully ,and which can be used for the further study both in vivo and in vitro .