CAJ | 학술논문

目的：通过探讨脂肪组织反应因子与心脏自主神经功能的关系，分析2型糖尿病患者心脏自主神经病变的危险因素，为预防糖尿病自主神经病变引发的急性冠脉综合征提供临床指导。方法随机选取30例新发的2型糖尿病病人并30例健康对照，分别测定其血浆基本生化指标，空腹血糖、胰岛素、C肽水平，以及脂肪组织反应因子IL-2、总脂联素、高分子量脂联素、瘦素的血浆浓度，通过HOMA2衡量胰岛功能。24小时动态心电检测分析HRV。结果糖尿病组IL-2浓度较对照组明显降低，总脂联素、高分子量脂联素、瘦素浓度显著降低（P＜0．05）；糖尿病组HRV各指标（SDNN、SDANN、rMSDD、LF、HF、LF/HF）与对照组相比均出现明显下降（P＜0．05）；IL-2、高分子量脂联素、瘦素浓度与HRV相关性显著（P＜0．05）。结论血浆IL-2、高分子量脂联素、瘦素浓度是2型糖尿病患者心脏自主功能病变的高危因素，可作为2型糖尿病并发急性冠脉综合征的预测指标应用于临床。
목적：통과탐토지방조직반응인자여심장자주신경공능적관계，분석2형당뇨병환자심장자주신경병변적위험인소，위예방당뇨병자주신경병변인발적급성관맥종합정제공림상지도。방법수궤선취30례신발적2형당뇨병병인병30례건강대조，분별측정기혈장기본생화지표，공복혈당、이도소、C태수평，이급지방조직반응인자IL-2、총지련소、고분자량지련소、수소적혈장농도，통과HOMA2형량이도공능。24소시동태심전검측분석HRV。결과당뇨병조IL-2농도교대조조명현강저，총지련소、고분자량지련소、수소농도현저강저（P＜0．05）；당뇨병조HRV각지표（SDNN、SDANN、rMSDD、LF、HF、LF/HF）여대조조상비균출현명현하강（P＜0．05）；IL-2、고분자량지련소、수소농도여HRV상관성현저（P＜0．05）。결론혈장IL-2、고분자량지련소、수소농도시2형당뇨병환자심장자주공능병변적고위인소，가작위2형당뇨병병발급성관맥종합정적예측지표응용우림상。
ObjectiveWe studied the relationship between cardiac autonomic imbalance andadipose tissue-derived inflammation in type 2 dia-betes, which aims to predicts increased cardiovascular risk and mortality.Methods30non -diabeticsand 30 diabetics were included.Biochemical measurements wereobtained, and insulin resistance was approximated.Cardiac autonomic function was assessed by HRV.Results Interleukin-6 was higher in diabetics, whiletheadiponectin and leptinwas lower.Heart rate variability was reduced in all diabetics.Interleukin-6,the high molecular weight adiponectin and leptincorrelated positivelywithmeasures of autonomic balance.Cardiacautonomic imbalance and inflammation occur early in di-abetes and are interrelated.ConclusionsCardiac autonomic imbalancecorrelates with the adipose tissue-derived inflammation seen early in type 2 dia-betes.