CAJ | 학술논문

目的研究清肝利胆口服液联合更昔洛韦治疗婴儿巨细胞病毒肝炎的临床疗效和安全性.方法将70例婴儿巨细胞病毒肝炎患儿随机分为治疗组和对照组,各35例.治疗组口服清肝利胆口服液,同时静脉滴注更昔洛韦；对照组静脉滴注更昔洛韦；疗程4周.观察两组疗效及不良反应.结果治疗组血清总胆红素、直接胆红素、谷丙转氨酶、r-谷氨酰转移酶恢复,肝脏回缩至正常,黄疸消退,与对照组相比,差异有统计学意义(P＜0.01)；治疗组有17例CMV-IgM转阴,对照组有16例,差异无显著性意义(P＞0.05).结论清肝利胆口服液联合更昔洛韦治疗婴儿巨细胞病毒肝炎,能有效恢患儿复肝功能,降酶退黄,无副作用,值得临床推广.但该治疗方法在CMV-IgM转阴上未见明显效果.
목적 연구청간리담구복액연합경석락위치료영인거세포병독간염적림상료효화안전성.방법 장70례영인거세포병독간염환인수궤분위치료조화대조조,각35례.치료조구복청간리담구복액,동시정맥적주경석락위；대조조정맥적주경석락위；료정4주.관찰량조료효급불량반응.결과 치료조혈청총담홍소、직접담홍소、곡병전안매、r-곡안선전이매회복,간장회축지정상,황달소퇴,여대조조상비,차이유통계학의의(P＜0.01)；치료조유17례CMV-IgM전음,대조조유16례,차이무현저성의의(P＞0.05).결론 청간리담구복액연합경석락위치료영인거세포병독간염,능유효회환인복간공능,강매퇴황,무부작용,치득림상추엄.단해치료방법재CMV-IgM전음상미견명현효과.
Objective To explore the efficacy and safety of Qingganlidan oral liquid combined with ganciclovir in the treatment of infants with cytomegalovirus hepatitis.Methods 70 infants with cytomegalovirus hepatitis were randomly divided into two groups,35 for each group.The study group was treated with Qingganlidan oral solution plus intravenous ganciclovir,while the control group received intravenous ganciclovir for 4 weeks.The efficacy and adverse reactions were observed.Results Serum total bilirubin,direct bilirubin examination,GPT,and r-GGT returned to normal,liver shrank to its normal size,jaundice subsided in the study group,as compared with the control group,with a statistical difference (P＜0.01).The negative rate of CMV-IgM did not differ significantly between the study group and the control group (17 patients vs.16 patients,P＞0.05).Conclusions Qingganlidan oral liquid combined with ganciclovir can effectively restore liver function,lower levels of aminotransferase,relieve jaundice,but has no side effects in the treatment of infants with cytomegalovirus hepatitis; it is worth popularizing clinically.But this therapy has no marked effect on negative changes in CMV-IgM.