CAJ | 학술논문

口腔托盘给药系统（DDDS）是在专业机械洁牙后用托盘局部输送药物的一种联合应用物理化学途径的口腔给药方法。DDDS由有储药池之称的个别托盘组成，贴附在牙体表面，借助于托盘的良好封闭作用，直接向牙体表面输送小剂量药物，使药物长时间保持有效的质量浓度，起到良好的治疗作用。通过DDDS给药，药物可长时间地保持有效质量浓度；减少口腔味觉改变、口腔烧灼感和细菌耐药情况的发生；用药灵活，可根据病情调整用药周期和药物配方；疗程可长可短，给药及移除药物方便。患者在家庭或办公时自行戴用托盘给药，减少了复诊次数，不会因复诊问题中断或延缓治疗。本文就DDDS托盘的制作，DDDS的使用，DDDS在牙体漂白中的应用、在治疗牙周病中的应用、在牙本质过敏治疗中的应用、在防龋中的应用等研究进展作一综述。
구강탁반급약계통（DDDS）시재전업궤계길아후용탁반국부수송약물적일충연합응용물이화학도경적구강급약방법。DDDS유유저약지지칭적개별탁반조성，첩부재아체표면，차조우탁반적량호봉폐작용，직접향아체표면수송소제량약물，사약물장시간보지유효적질량농도，기도량호적치료작용。통과DDDS급약，약물가장시간지보지유효질량농도；감소구강미각개변、구강소작감화세균내약정황적발생；용약령활，가근거병정조정용약주기화약물배방；료정가장가단，급약급이제약물방편。환자재가정혹판공시자행대용탁반급약，감소료복진차수，불회인복진문제중단혹연완치료。본문취DDDS탁반적제작，DDDS적사용，DDDS재아체표백중적응용、재치료아주병중적응용、재아본질과민치료중적응용、재방우중적응용등연구진전작일종술。
The dental drug delivery system(DDDS), in combination with professional mechanical tooth cleaning and local application of drugs using trays, may be used as a physicochemical method to deliver drugs. The DDDS consists of individual trays called drug retainers that come in contact with the tooth surface and deliver drugs. The application maintains clinical efficacy and reduces altered taste, burning sensation, and drug-resistance in the mouth. The system can easily adjust the drugs and medication cycle. The treatment can be long or short, and removing the drugs can be convenient. Patients can wear their own trays at home or in the office, and they need not set up appointments. The tray fabrication, method of application, and current application of DDDS in tooth bleaching, treatment of periodontal disease, treatment of dentine hypersensitivity, and prevention of dental caries are reviewed in this article.