CAJ | 학술논문

牙槽骨再生是牙周组织疾病治疗的根本。牙槽骨发生属于膜内成骨，成骨细胞来源于多潜能神经嵴牙囊间质细胞，伴随着牙体的发生而发生。牙胚由成釉器、牙乳头和牙囊组成，而牙囊则形成牙骨质、牙周膜和牙槽骨。骨形态发生蛋白（BMP）可启动、促进和调节骨的发生、发育、生长、重塑和修复。核心结合因子1可使牙囊间质细胞向成骨细胞分化，对膜内成骨和软骨内成骨有控制作用。成纤维细胞生长因子通过调控骨干细胞复制，成骨细胞分化和程序性死亡，各种细胞及相关因子的表达来控制骨形成。WNT在BMP的刺激下促进成骨细胞分化，增强BMP诱导下的Ⅰ型胶原、特殊骨基质蛋白和骨钙蛋白表达。声音刺猬蛋白、转化生长因子β和肌节同源盒蛋白2在牙槽骨和牙骨质中表达强烈，其基因突变可致牙槽骨丧失。本文就牙槽骨发生与牙囊间的关系以及参与牙槽骨发生的细胞因子等研究进展作一综述。
아조골재생시아주조직질병치료적근본。아조골발생속우막내성골，성골세포래원우다잠능신경척아낭간질세포，반수착아체적발생이발생。아배유성유기、아유두화아낭조성，이아낭칙형성아골질、아주막화아조골。골형태발생단백（BMP）가계동、촉진화조절골적발생、발육、생장、중소화수복。핵심결합인자1가사아낭간질세포향성골세포분화，대막내성골화연골내성골유공제작용。성섬유세포생장인자통과조공골간세포복제，성골세포분화화정서성사망，각충세포급상관인자적표체래공제골형성。WNT재BMP적자격하촉진성골세포분화，증강BMP유도하적Ⅰ형효원、특수골기질단백화골개단백표체。성음자위단백、전화생장인자β화기절동원합단백2재아조골화아골질중표체강렬，기기인돌변가치아조골상실。본문취아조골발생여아낭간적관계이급삼여아조골발생적세포인자등연구진전작일종술。
Absorption and loss of alveolar bone are some of the main reasons of tooth loss. Therefore, clinics must understand how to reconstruct alveolar bone. To date, treatment strategies to rescue or regenerate the alveolar bone are limited. The process of developing biological alveolar bone formation in the early stage may help to understand the mechanism of bone regeneration and benefit clinical treatment. Alveolar bone is partially derived from dental follicle cells. Many growth factors and transcription factors are involved in the development of alveolar bone. In this review, the relationship between alveolar bone formation and many factors will be discussed in detail. This review also highlights recent advances in understanding alveolar bone development with and without varying factors.