CAJ | 학술논문

细胞自噬相关蛋白（ATG）8-磷脂酰乙醇胺（PE）是迄今唯一定位于细胞自噬体膜上的蛋白质，与细胞自噬体的形成密切相关。细胞自噬泡通过细胞骨架蛋白运送至溶酶体，其外膜与溶酶体膜结合形成细胞自噬溶酶体。细胞自噬体内膜及其包含的内容物在酸性环境和溶酶体酶的共同作用下降解所产生的大分子通过膜的通透酶释放入细胞质。ATG8-PE连接系统是调控细胞自噬的核心，当细胞受到细胞自噬诱导时，大量的ATG8蛋白以膜结合形式定位于细胞自噬体的内膜和外膜上，因此ATG8-PE是检测细胞自噬的良好标志物。自噬体膜上任何ATG复合物的变异，都将导致细胞自噬体形成缺陷。在某些人类的肿瘤，如结肠癌、乳腺癌和肺癌中可观察到ATG蛋白表达的增加，微管相关蛋白1轻链3-Ⅱ缺失可能与肿瘤的不良预后有关。本文就细胞自噬及其分子机制、ATG8连接系统、ATG在头颈部恶性肿瘤中的表达等研究进展作一综述。
세포자서상관단백（ATG）8-린지선을순알（PE）시흘금유일정위우세포자서체막상적단백질，여세포자서체적형성밀절상관。세포자서포통과세포골가단백운송지용매체，기외막여용매체막결합형성세포자서용매체。세포자서체내막급기포함적내용물재산성배경화용매체매적공동작용하강해소산생적대분자통과막적통투매석방입세포질。ATG8-PE련접계통시조공세포자서적핵심，당세포수도세포자서유도시，대량적ATG8단백이막결합형식정위우세포자서체적내막화외막상，인차ATG8-PE시검측세포자서적량호표지물。자서체막상임하ATG복합물적변이，도장도치세포자서체형성결함。재모사인류적종류，여결장암、유선암화폐암중가관찰도ATG단백표체적증가，미관상관단백1경련3-Ⅱ결실가능여종류적불량예후유관。본문취세포자서급기분자궤제、ATG8련접계통、ATG재두경부악성종류중적표체등연구진전작일종술。
Autophagy-related gene product8(ATG8) phosphatidylethanolamine(PE) is a unique protein that is located on the autophagic membrane, and is frequently related to the formation of autophagosomes. Autophagosomes are transported to the lysosomes through cytoskeletal proteins, and then their outer membranes fuse with the membrane of lysosomes and form autolysosomes. Autophagosome and its contents are degraded to macromolecules by lysosomal enzymes in acidic environment and are released into the cytoplasm through membrane permeability. The ATG8-PE connection system is the core regulator of autophagy. A mass of membrane-bound ATG8 are located in the cell autophagy intima and adventitia when cells are induced by autophagy. Thus, ATG8-PE is a good marker for detecting autophagy. Any variation of ATG complexes of autophagic membrane will lead to the formation of defects of autophagosomes. Human tumors, such as colon, breast and lung cancer, can increase ATG protein expression. The connection of microtubule-associated protein 1 light chain 3-Ⅱ may be missed with poor prognosis. This review concludes with a presentation of research advances concerning the molecular mechanism of autophagy, ATG8 connection system, and its expression in head and neck malignant tumors.