中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
7期
1298-1302
,共5页
许茜%宋丽雪%丁媛媛%邸晓辉%许景峰%李丽%马建
許茜%宋麗雪%丁媛媛%邸曉輝%許景峰%李麗%馬建
허천%송려설%정원원%저효휘%허경봉%리려%마건
结直肠肿瘤%UGT1A7%UGT1A8%UGT基因多态性
結直腸腫瘤%UGT1A7%UGT1A8%UGT基因多態性
결직장종류%UGT1A7%UGT1A8%UGT기인다태성
Colorectal cancer%UGT1A7%UGT1A8%UGT polymorphism
目的：研究我国健康人与结直肠癌患者UGT1A7和UGT1A8基因多态性分布与结直肠癌的相关性。方法提取297例健康受试者和301例结直肠癌患者血样标本的DNA，确定UGT1A7和UGT1A8基因型，研究UGT1A7和UGT1A8基因多态性分布与结直肠癌的相关性。结果结直肠癌患者组携带UGT1A7*2*2和UGT1A7*3*3基因型分别为14.29%和15.28%，明显高于健康受试组的3.70%和3.37%。两组比较，P＝0.013和0.002，OR（95%CI）分别为4.31（1.12～6.33）和6.32（2.10～9.61）；结直肠癌患者组携带UGT1A8*1*3基因型为16.94%，明显高于健康受试组的3.03%（P＜0.001），OR（95% CI）为4.65（1.87～6.82）；携带UGT1A8*2*3基因型18.94%，显著高于健康受试组的4.38%（P＜0.000），OR（95% CI）为8.46（2.18～11.54）。结论 UGT1A7*2*2和UGT1A7*3*3、UGT1A8*1*3和UGT1A8*2*3与结直肠癌相关联，是结直肠癌的风险基因。其中UGT1A7*3*3和UGT1A8*2*3是结直肠癌的高风险基因，与结直肠癌密切相关联。
目的：研究我國健康人與結直腸癌患者UGT1A7和UGT1A8基因多態性分佈與結直腸癌的相關性。方法提取297例健康受試者和301例結直腸癌患者血樣標本的DNA，確定UGT1A7和UGT1A8基因型，研究UGT1A7和UGT1A8基因多態性分佈與結直腸癌的相關性。結果結直腸癌患者組攜帶UGT1A7*2*2和UGT1A7*3*3基因型分彆為14.29%和15.28%，明顯高于健康受試組的3.70%和3.37%。兩組比較，P＝0.013和0.002，OR（95%CI）分彆為4.31（1.12～6.33）和6.32（2.10～9.61）；結直腸癌患者組攜帶UGT1A8*1*3基因型為16.94%，明顯高于健康受試組的3.03%（P＜0.001），OR（95% CI）為4.65（1.87～6.82）；攜帶UGT1A8*2*3基因型18.94%，顯著高于健康受試組的4.38%（P＜0.000），OR（95% CI）為8.46（2.18～11.54）。結論 UGT1A7*2*2和UGT1A7*3*3、UGT1A8*1*3和UGT1A8*2*3與結直腸癌相關聯，是結直腸癌的風險基因。其中UGT1A7*3*3和UGT1A8*2*3是結直腸癌的高風險基因，與結直腸癌密切相關聯。
목적：연구아국건강인여결직장암환자UGT1A7화UGT1A8기인다태성분포여결직장암적상관성。방법제취297례건강수시자화301례결직장암환자혈양표본적DNA，학정UGT1A7화UGT1A8기인형，연구UGT1A7화UGT1A8기인다태성분포여결직장암적상관성。결과결직장암환자조휴대UGT1A7*2*2화UGT1A7*3*3기인형분별위14.29%화15.28%，명현고우건강수시조적3.70%화3.37%。량조비교，P＝0.013화0.002，OR（95%CI）분별위4.31（1.12～6.33）화6.32（2.10～9.61）；결직장암환자조휴대UGT1A8*1*3기인형위16.94%，명현고우건강수시조적3.03%（P＜0.001），OR（95% CI）위4.65（1.87～6.82）；휴대UGT1A8*2*3기인형18.94%，현저고우건강수시조적4.38%（P＜0.000），OR（95% CI）위8.46（2.18～11.54）。결론 UGT1A7*2*2화UGT1A7*3*3、UGT1A8*1*3화UGT1A8*2*3여결직장암상관련，시결직장암적풍험기인。기중UGT1A7*3*3화UGT1A8*2*3시결직장암적고풍험기인，여결직장암밀절상관련。
Objective To study the allelic frequency of UGT1A7 and UGT1A8 genes, and relationship between the mutations of UGT1A7 and UGT1A8 genes with colorectal cancer. Methods To determine the allelic frequency of the UGT1A7 and UGT1A8 mutant in a group of 297 healthy subjects and 301 colorectal cancer. To study the relationship of UGT1A7 and UGT1A8 gene polymorphism with colorectal cancer. Results The allelic frequency of the UGT1A7*2*2 and UGT1A7*3*3 were 14.29%and 15.28%in colorectal cancer respectively, obviously super 3.70%and 3.37%in healthy subjects, to compare the allelic frequency of two groups, P=0.013, OR=4.31(95%CI:1.12-6.33) and P=0.002, OR=6.32 (95%CI:2.10-9.61) respectively. they were significant difference. The allelic frequency of the UGT1A8*1*3 were 16.94%and 3.03%in colorectal cancer and healthy subjects respectively, and had also significant difference, P<0.000, OR=8.46(95%CI:2.18-11.54). Conclusions The gene mutation of the UGT1A7*2*2, UGT1A7*3*3, UGT1A8*1*3 and UGT1A8*2*3 were correlation with colorectal cancer. The gene mutation of the UGT1A7*2*2, UGT1A7*3*3, UGT1A8*1*3 and UGT1A8*2*3 may increase risk of the colorectal cancer, and UGT1A7*3*3, UGT1A8*2*3 gene mutation were high risk predisposing gene of the colorectal cancer.
