CAJ | 학술논문

目的：探讨血抵抗素水平与新疆维吾尔族人非酒精性脂肪肝（NAFL）、胰岛素抵抗的关系。方法：选择脂肪肝患者287例（脂肪肝组）和健康对照206例（正常对照组），其中维吾尔族378例，汉族115人，抽取空腹静脉血检测血脂、胰岛素、血糖及抵抗素水平，计算BMI、HOMA-IR ，分析抵抗素与NAFL及上述指标的关系。结果：维吾尔族研究对象的脂肪肝构成比、血清抵抗素水平显著高于汉族研究对象。在维吾尔族研究对象中，校正影响因素后，与正常组相比，脂肪肝组血清抵抗素、HOM A-IR水平升高；而脂肪肝患病率、BMI、SBP、TC、LDL-c、HOMA-IR水平随着血清抵抗素的增高呈现上升趋势；Logistic回归分析结果提示：在校正性别、年龄、BMI、SBP、DBP、HOMA-IR、TC、HDL-c、LDL-c、TG等影响因素后，以血清抵抗素三分位最低层为对照，在第二、三分位层时患脂肪肝的OR值分别为7．048、8．085；胰岛素抵抗的OR值分别为2．892、3．699；偏相关分析提示：校正了年龄、性别、SBP、DBP、TG、TC、HDL-c、LDL-c后，HOMA-IR与抵抗素水平正相关。结论：抵抗素水平升高是维吾尔族NAFL 的独立危险因素，NAFL 患者血抵抗素增高与胰岛素抵抗密切相关。
목적：탐토혈저항소수평여신강유오이족인비주정성지방간（NAFL）、이도소저항적관계。방법：선택지방간환자287례（지방간조）화건강대조206례（정상대조조），기중유오이족378례，한족115인，추취공복정맥혈검측혈지、이도소、혈당급저항소수평，계산BMI、HOMA-IR ，분석저항소여NAFL급상술지표적관계。결과：유오이족연구대상적지방간구성비、혈청저항소수평현저고우한족연구대상。재유오이족연구대상중，교정영향인소후，여정상조상비，지방간조혈청저항소、HOM A-IR수평승고；이지방간환병솔、BMI、SBP、TC、LDL-c、HOMA-IR수평수착혈청저항소적증고정현상승추세；Logistic회귀분석결과제시：재교정성별、년령、BMI、SBP、DBP、HOMA-IR、TC、HDL-c、LDL-c、TG등영향인소후，이혈청저항소삼분위최저층위대조，재제이、삼분위층시환지방간적OR치분별위7．048、8．085；이도소저항적OR치분별위2．892、3．699；편상관분석제시：교정료년령、성별、SBP、DBP、TG、TC、HDL-c、LDL-c후，HOMA-IR여저항소수평정상관。결론：저항소수평승고시유오이족NAFL 적독립위험인소，NAFL 환자혈저항소증고여이도소저항밀절상관。
Objective :To investigate the relationship among resistin ,insulin resistance and Non-Alcoholic Fatty Liver (NAFL) in Uygur of Xinjiang .Methods :We recruited 287 patients with NAFL (case group) and 206 healthy controls (control group) ,including 378 Uygur and 115 Han individuals .Fasting blood were obtained from all subjects .Then we measured the serum lipids ,insulin ,blood glucose and resistin levels in all subjects and also calculated BMI ,HOMA-IR .We analyzed the relationship among resistin ,Non-Alcoholic NAFL and all above-mentioned profiles finally .Results : The constituent ratios of the fatty liver and serum resistin level were significantly higher in Uygur than Han subjects .After adjusting of sex ,age ,BMI ,SBP ,DBP ,TC ,HDL-c ,LDL-c ,TG and HOMA-IR ,compared with the normal group ,the a serum resistin level in NAFL group was increased and has significant difference in Uygur .The prevalence of NAFL and BMI ,DBP ,TC ,TG ,HOMA-IR levels were increased while the resistin levels were increase .The results of logistic regression analysis suggested that after adjusting of sex ,age ,BMI ,SBP ,DBP ,HOMA-IR ,TC ,HDL-c ,LDL-c ,TG ,compared with the lowest resistin levels group , the OR value of NAFL of the second ,third group were 7 .048 and 8 .085 respectively ;the OR value of insulin resistance of the second ,third group were 2 .892 and 3 .699 respectively .After adjusted age ,sex ,SBP ,DBP ,TG ,TC , HDL-c ,LDL-c ,partial correlation analysis suggests that HOMA-IR was positive correlation to serum resistin level . Conclusion :The higher resistin level is an independent risk factor for NAFL in Uygur .Resistin is positive correlation to insulin resistance .