CAJ | 학술논문

目的：探讨冠心病患者外周血血管生成素-1（Ang-1）、血管生成素-2（Ang-2）、基质金属蛋白酶-2（MMP-2）的表达及Ang-2与MMP-2水平的相关性。方法：选取冠心病患者126例，其中急性心肌梗死（AMI）42例，不稳定性心绞痛（UAP）42例，稳定性心绞痛（SAP）42例，同时选择45例体检健康者为对照组。应用Gensini积分法对冠心病病变血管狭窄程度进行定量评估，测定血浆Ang-1、Ang-2及MM P-2浓度，并对Ang-2和MM P-2水平进行相关性分析。结果：急性冠脉综合征组（AMI组和UAP组）血浆Ang-2和MM P-2水平均明显高于对照组和SAP组，差异具有统计学意义，而Ang-1在各组间无显著性差异。相关性分析显示冠心病组Gensini积分与Ang-2和MMP-2均呈明显的正相关，Ang-2与MMP-2水平呈显著的正相关。结论：Ang-2在急性冠脉综合征患者外周血中表达增加，可能系Ang-2促进MM P-2的表达引起斑块的稳定性降低而发挥作用。
목적：탐토관심병환자외주혈혈관생성소-1（Ang-1）、혈관생성소-2（Ang-2）、기질금속단백매-2（MMP-2）적표체급Ang-2여MMP-2수평적상관성。방법：선취관심병환자126례，기중급성심기경사（AMI）42례，불은정성심교통（UAP）42례，은정성심교통（SAP）42례，동시선택45례체검건강자위대조조。응용Gensini적분법대관심병병변혈관협착정도진행정량평고，측정혈장Ang-1、Ang-2급MM P-2농도，병대Ang-2화MM P-2수평진행상관성분석。결과：급성관맥종합정조（AMI조화UAP조）혈장Ang-2화MM P-2수평균명현고우대조조화SAP조，차이구유통계학의의，이Ang-1재각조간무현저성차이。상관성분석현시관심병조Gensini적분여Ang-2화MMP-2균정명현적정상관，Ang-2여MMP-2수평정현저적정상관。결론：Ang-2재급성관맥종합정환자외주혈중표체증가，가능계Ang-2촉진MM P-2적표체인기반괴적은정성강저이발휘작용。
Objective:To investigate the expression of angiopoietin-1 (Ang-1) ,angiopoietin-2 (Ang-2) and matrix metalloproteinase-2 (MMP-2) in patients with coronary heart disease and the correlation between Ang-2 and MMP-2 .Methods :126 patients with coronary heart disease were divided into three groups ,including 42 with a-cute myocardial infarction (AMI) ,42 with unstable angina pectoris (UAP) and 42 with stable angina pectoris (SAP) .Another 45 healthy subjects served as the control group .The severity of coronary artery disease in patients with coronary heart disease was evaluated by Gensini score .Plasma concentration of Ang-1 ,Ang-2 and MMP-2 was measured .Results :The concentration of plasma Ang-2 and MM P-2 in patients with acute coronary syndrome group (AMI and UAP group ) were significantly higher than control group and SAP group with significant differences ,but not Ang-1 .Ang-2 and MMP-2 levels were positively correlated with Gensini score .There were positively correlation between Ang-2 and MMP-2 levels .Conclusion :Ang-2 levels in peripheral blood are higher in patients with acute coronary syndrome .Ang-2 stimulating MM P-2 expression and reducing plaque stability might play a role .