中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2014年
3期
288-290
,共3页
纪涛%朱水波%董永强%张晓明%梁江水%殷桂林
紀濤%硃水波%董永彊%張曉明%樑江水%慇桂林
기도%주수파%동영강%장효명%량강수%은계림
癌,非小细胞肺%受体,CXCR4%丝氨酸蛋白酶抑制剂
癌,非小細胞肺%受體,CXCR4%絲氨痠蛋白酶抑製劑
암,비소세포폐%수체,CXCR4%사안산단백매억제제
Carcinoma,non-small-cell lung%Receptors,CXCR4%Serine proteinase inhibitors
目的：探讨非小细胞肺癌（NSCLC）组织中组织因子途径抑制物-2（TFPI-2）和趋化因子受体-4（CXCR4）蛋白表达与临床病理特征及预后的关系。方法应用免疫组织化学方法检测60例NSCLC癌组织及癌旁组织及10例正常组织中的TFPI-2及CXCR4，并分析TFPI-2和CXCR4的表达水平与性别、年龄、组织类型、分化程度、TNM分期及淋巴结转移的关系。结果 TFPI-2在NSCLC组织中的表达水平明显低于癌旁组织和正常组织，CXCR4表达水平在癌组织中明显高于癌旁组织和正常组织（P＜0．05）。TFPI-2和CXCR4表达与性别、年龄、组织类型、分化程度、TNM分期无关，仅仅与淋巴结转移有关（P＜0．05）。TFPI-2和CX-CR4在NSCLC组织中呈现负相关（r＝-0．26，P＜0．05）。结论 TFPI-2可能通过抑制增高的CXCR4表达来影响肿瘤的迁徙转移。
目的：探討非小細胞肺癌（NSCLC）組織中組織因子途徑抑製物-2（TFPI-2）和趨化因子受體-4（CXCR4）蛋白錶達與臨床病理特徵及預後的關繫。方法應用免疫組織化學方法檢測60例NSCLC癌組織及癌徬組織及10例正常組織中的TFPI-2及CXCR4，併分析TFPI-2和CXCR4的錶達水平與性彆、年齡、組織類型、分化程度、TNM分期及淋巴結轉移的關繫。結果 TFPI-2在NSCLC組織中的錶達水平明顯低于癌徬組織和正常組織，CXCR4錶達水平在癌組織中明顯高于癌徬組織和正常組織（P＜0．05）。TFPI-2和CXCR4錶達與性彆、年齡、組織類型、分化程度、TNM分期無關，僅僅與淋巴結轉移有關（P＜0．05）。TFPI-2和CX-CR4在NSCLC組織中呈現負相關（r＝-0．26，P＜0．05）。結論 TFPI-2可能通過抑製增高的CXCR4錶達來影響腫瘤的遷徙轉移。
목적：탐토비소세포폐암（NSCLC）조직중조직인자도경억제물-2（TFPI-2）화추화인자수체-4（CXCR4）단백표체여림상병리특정급예후적관계。방법응용면역조직화학방법검측60례NSCLC암조직급암방조직급10례정상조직중적TFPI-2급CXCR4，병분석TFPI-2화CXCR4적표체수평여성별、년령、조직류형、분화정도、TNM분기급림파결전이적관계。결과 TFPI-2재NSCLC조직중적표체수평명현저우암방조직화정상조직，CXCR4표체수평재암조직중명현고우암방조직화정상조직（P＜0．05）。TFPI-2화CXCR4표체여성별、년령、조직류형、분화정도、TNM분기무관，부부여림파결전이유관（P＜0．05）。TFPI-2화CX-CR4재NSCLC조직중정현부상관（r＝-0．26，P＜0．05）。결론 TFPI-2가능통과억제증고적CXCR4표체래영향종류적천사전이。
Objective To explore the expression of tissue factor way inhibitor-2 (TFPI-2 )and chemokine receptor-4 (CXCR4)protein,clinical pathological characteristics and prognosis in the non-small cell lung cancer (NSCLC).Methods The expression of TFPI-2 and CXCR4 in tumor issues and adjacent normal lung tissues collect-ed from 60 NSCLC patients,and normal tissue collected from 10 healthy subjects were detected by immunohistochem-istry.The correlation of the level of CXCR4 and TFPI-2 and the gender,age,histological type,degree of differentia-tion,lymph node metastasis,TNM stage was analyzed.Results The level of TFPI-2 in tumor tissues was significantly lower than that in carcinoma adjacent tissues and normal tissues,and the level of CXCR4 in the tumor tissue is obvi-ously higher than that in the carcinoma adjacent tissues and normal tissues (P<0.05 ).There was an correlation of TFPI-2 and CXCR4 level with lymph node metastasis (P<0.05 ),but this correlation was not seen in the gender, age,histological type,degree of differentiation and TNM staging.The TFPI-2level was negatively correlated with CX-CR4 level in NSCLC (r=0.26,P<0.05 ).Conclusions TFPI-2 may influence the migration of tumor metastasis through the inhibition of increased CXCR4 expression.
