CAJ | 학술논문

目的：探讨早发型子痫前期患者血清脂肪型脂肪酸结合蛋白（FABP4）水平变化及其与胰岛素抵抗的关系。方法：选取2010年10月～2012年10月在青岛医学院第二附属医院产科住院分娩的早发型子痫前期（发病时孕周≤34周）患者30例为观察组，同期我院产科门诊检查的孕妇30例为对照组，采用酶联免疫吸附法检测两组空腹血清脂肪型脂肪酸结合蛋白（FABP4），同时测定各组的血压、体重指数、血糖、空腹胰岛素等指标，采用稳态模型法计算胰岛素抵抗指数。结果：①观察组血清FABP4水平显著高于对照组（P＜0.05）；②观察组胰岛素抵抗指数显著高于对照组（P＜0.05）；③观察组血清FABP4与胰岛素抵抗指数呈正相关（r=0.96，P≤0.05）。结论：FABP4与胰岛素抵抗在早发型子痫前期发病中起重要作用。
목적：탐토조발형자간전기환자혈청지방형지방산결합단백（FABP4）수평변화급기여이도소저항적관계。방법：선취2010년10월～2012년10월재청도의학원제이부속의원산과주원분면적조발형자간전기（발병시잉주≤34주）환자30례위관찰조，동기아원산과문진검사적잉부30례위대조조，채용매련면역흡부법검측량조공복혈청지방형지방산결합단백（FABP4），동시측정각조적혈압、체중지수、혈당、공복이도소등지표，채용은태모형법계산이도소저항지수。결과：①관찰조혈청FABP4수평현저고우대조조（P＜0.05）；②관찰조이도소저항지수현저고우대조조（P＜0.05）；③관찰조혈청FABP4여이도소저항지수정정상관（r=0.96，P≤0.05）。결론：FABP4여이도소저항재조발형자간전기발병중기중요작용。
Objective:To study relationship between serum adipocyte fatty acid-binding protein level and insulin resistance of patients with Early-onset preeclampsia.Methods:A total of 30 women with Early-onset PE(presented at≤34 weeks of gestatio)and 30 normal outpatient pregnant women control participated in this study.AII are admitted to Second Affiliated Hospital of Qingdao Medical University for delivery from October 2010 to October 2012.Enzyme-linked immunosorbent assay (ELISA)was used to detect FABP4, fasting serum glucose,fasting insulin (FINS) in matemal serum. Using the homeostasis model calculated insulin resistance index. Results:①The serum level of adipocyte fatty acid-binding protein of pregnant women with Early-onset preeclampsia was significantly higher than that of those normal pregnant women (P<0.05); ②The insulin resistance index of pregnant women with Early-onset preeclampsia was significantly higher than that of those normal pregnant women(P<0.05):③The serum level of adipocyte fatty acid-binding protein was positive correlated with insulin resistance index (r=0.96,P≤0.05).Condusion:Adipocyte fatty acid-binding protein and insulin resistance may play important roles in pathogenesis of Early-onset preeclampsia.