CAJ | 학술논문

肿瘤患者大多术前已存在不同程度的营养不良及免疫功能障碍，而手术的创伤和术后应激反应引起的分解代谢加强更加重了营养不良和免疫抑制，导致机体抵抗力降低，并发症增多，死亡率增高和住院时间延长。全肠外营养（ TPN）支持可增加肿瘤患者特别是术后恶性肿瘤患者肌肉组织和肝脏内糖原的贮存，使不能正常进食或超高代谢肿瘤患者维持较好的营养状态，增强自身免疫能力，提高其生存质量。此外，很多术后恶性肿瘤患者在术后营养不良的情况下，还在多次进行放、化疗，不但机体耐受能力下降，明显影响化疗效果，还严重影响患者生活及生存质量。因此，关注术后恶性肿瘤患者营养支持需求，特别是营养的平衡供给尤为重要。本文就TPN在术后恶性肿瘤的应用状况与研究进展做一综述。
종류환자대다술전이존재불동정도적영양불량급면역공능장애，이수술적창상화술후응격반응인기적분해대사가강경가중료영양불량화면역억제，도치궤체저항력강저，병발증증다，사망솔증고화주원시간연장。전장외영양（ TPN）지지가증가종류환자특별시술후악성종류환자기육조직화간장내당원적저존，사불능정상진식혹초고대사종류환자유지교호적영양상태，증강자신면역능력，제고기생존질량。차외，흔다술후악성종류환자재술후영양불량적정황하，환재다차진행방、화료，불단궤체내수능력하강，명현영향화료효과，환엄중영향환자생활급생존질량。인차，관주술후악성종류환자영양지지수구，특별시영양적평형공급우위중요。본문취TPN재술후악성종류적응용상황여연구진전주일종술。
Various degree of malnutrition and immunedysfunction have already existed during preoperative period in cancer patients ,postoperative hypermetabolism caused by wounds and stress reactions further deteriorate the pa -tient′s conditions ,resulting in reduced body resistance ,increased complications and mortality and prolonged hospitali-zation.TPN could help to enhance storage of muscle and hepatic glycogen ,maintain good nutritional status for patiens undergoing hypermetabolism or abnormal food intake , strengthen autoimmunity and increase lift quality.Moreover , many postoperative cancer patients have to undergo radiotherapy and chemotherapy despite of the poor nutrition sta -tus, leading to decreasing tolerance , imperfect treating effect and exacerbating life quality and survival rate.Therefore ,it′s of great importance to pay attention to nutrition support in postoperative malignant tumor patients , especially balanced supplement of nutrition.Our review aimed to overview current application status and research de-velopment on TPN in postoperative malignant tumor nutrition support.