CAJ | 학술논문

目的：修订内消瘰疬丸（浓缩丸）的质量标准，增加薄层色谱法和高效液相色谱法，提高药品的质量标准。方法采用薄层色谱法对薄荷、连翘进行鉴别；采用高效液相色谱法测定处方中夏枯草迷迭香酸及玄参哈巴俄苷的含量。结果薄层色谱斑点清晰，阴性对照无干扰。迷迭香酸在0.03934～0.27538μg 内有良好的线性关系，r＝0.99998，加样回收率为98.33％，相对标准偏差（relative standard deviation，RSD）为2.27％；哈巴俄苷在0.06016～0.24064μg 内有良好的线性关系，r ＝0.99987，加样回收率为98.26％，RSD 为2.17％。结论提高内消瘰疬丸（浓缩丸）的标准，可更好地控制其质量。
목적：수정내소라력환（농축환）적질량표준，증가박층색보법화고효액상색보법，제고약품적질량표준。방법채용박층색보법대박하、련교진행감별；채용고효액상색보법측정처방중하고초미질향산급현삼합파아감적함량。결과박층색보반점청석，음성대조무간우。미질향산재0.03934～0.27538μg 내유량호적선성관계，r＝0.99998，가양회수솔위98.33％，상대표준편차（relative standard deviation，RSD）위2.27％；합파아감재0.06016～0.24064μg 내유량호적선성관계，r ＝0.99987，가양회수솔위98.26％，RSD 위2.17％。결론제고내소라력환（농축환）적표준，가경호지공제기질량。
Objective To revise the quality of Neixiao Luoli pill, through thin layer chroma-tography (TLC) and high performance liquid chromatography (HPLC) to improve the quality stan-dard of the drug.Methods On the original basis, the TLC identification of forsythia and determina-tion the content of rosemary acid and harpagoside by HPLC were measured.Results The spots were clear and nagative controls were not interfered.Rosemary acid presented a good linear realationship in the range of 0.039 34 - 0.275 38 μg (r =0.999 98).The average recovery was 98.33%, RSD was 2.27%.Harpagoside presented a good linear realationship in the range of 0.060 16 - 0.240 64μg (r=0.999 87).The average recovery was 98.26%, RSD was 2.17%.Conclusion The stan-dard of Neixiao Luoli pill was developed and improved for better quality control.