CAJ | 학술논문

目的：了解贝那普利联合苯磺酸氨氯地平的联合降压治疗对老年单纯收缩期高血压（isolated systolic hypertension，ISH)的安全性及疗效。方法200例老年ISH患者随机分为治疗组100例，采用贝那普利联合苯磺酸氨氯地平治疗；对照组100例单用贝那普利治疗，4周后对两组的降压有效率，不良反应等指标进行观察。结果4周治疗组有效率为97.0%(97/100)，明显高于对照组，差异有显著性(P<0.05)。两组治疗前收缩压和舒张压比较P>0.05，差异无统计学意义；降压治疗4周后，两组收缩压比较P<0.05，差异有统计学意义；治疗组的降压有效率显著高于对照组，P<0.05，差异有统计学意义；治疗组和对照组出现严重不良反应停药者。结论苯磺酸氨氯地平联合贝那普利治疗老年ISH安全有效，值得各医院推广应用。
목적：료해패나보리연합분광산안록지평적연합강압치료대노년단순수축기고혈압（isolated systolic hypertension，ISH)적안전성급료효。방법200례노년ISH환자수궤분위치료조100례，채용패나보리연합분광산안록지평치료；대조조100례단용패나보리치료，4주후대량조적강압유효솔，불량반응등지표진행관찰。결과4주치료조유효솔위97.0%(97/100)，명현고우대조조，차이유현저성(P<0.05)。량조치료전수축압화서장압비교P>0.05，차이무통계학의의；강압치료4주후，량조수축압비교P<0.05，차이유통계학의의；치료조적강압유효솔현저고우대조조，P<0.05，차이유통계학의의；치료조화대조조출현엄중불량반응정약자。결론분광산안록지평연합패나보리치료노년ISH안전유효，치득각의원추엄응용。
Objective To research the effect of amlodipine besylate and benazepril on older isolated systolic hypertension (ISH). Methods 200 patients with hypertension were randomly divided into treatment group (100 cases) treated with amlodipine besylate and benazepril and control group (100 cases) treated with benazepril. The therapeutic effects and adverse effect were observed. Results The effective rate of treatment group was higher than that of control group. Conclusion It is effective to treat older isolated systolic hypertension with amlodipine besylate and benazepril.