CAJ | 학술논문

目的：探讨阿司匹林致不良反应（ ADR）发生的一般规律及特点，为临床合理用药提供参考。方法筛选某院2012年4月至2013年9月间患者病例136例，并按患者性别、年龄、用药情况、ADR类型及临床表现等进行分类，并统计分析。结果发生ADR的患者男性多于女性，老人及儿童更易发作；主要ADR症状以消化系统症状较为多见；合并用药引发不良反应的可能性较高；使用肠溶型阿司匹林更为安全；多种原因导致患者用药不当进而引发不良反应。结论阿司匹林致ADR的临床表现复杂多样，最严重的可能引起死亡，其ADR的危害性值得重视。大众对阿司匹林的使用存在误区，临床医师、药师应注意指导患者合理用药、安全用药。
목적：탐토아사필림치불량반응（ ADR）발생적일반규률급특점，위림상합리용약제공삼고。방법사선모원2012년4월지2013년9월간환자병례136례，병안환자성별、년령、용약정황、ADR류형급림상표현등진행분류，병통계분석。결과발생ADR적환자남성다우녀성，노인급인동경역발작；주요ADR증상이소화계통증상교위다견；합병용약인발불량반응적가능성교고；사용장용형아사필림경위안전；다충원인도치환자용약불당진이인발불량반응。결론아사필림치ADR적림상표현복잡다양，최엄중적가능인기사망，기ADR적위해성치득중시。대음대아사필림적사용존재오구，림상의사、약사응주의지도환자합리용약、안전용약。
Objective To evaluate the general regularity and characteristics of adverse drug reaction ( ADR) induced by aspirin,and to provide reference for safe and rational clinical drug use .Methods 136 cases during April 2012 to September 2013 are collected in our hospital and analyzed statistically in respect of patients'gender,age,medication, types and clinical manifestation of ADR .Results Male and the old and children are more likely to have ADR;Most ADR symptoms are mainly related to digestive system .Mixed drugs usage has a higher possibility to induce ADR;En-teric aspirin is safer;Multiple reasons result in improper use of aspirin and ADR .Conclusion ADR induced by as-pirin has various symptoms ,even death cases .Common patients have misunderstanding with use of aspirin ,so clinical doctors and pharmacists should give patients introductions for rational and safe use of drugs .