CAJ | 학술논문

胶质瘤是中枢神经系统难治性肿瘤，冷冻消融治疗作为一种新兴的肿瘤治疗技术在胶质瘤治疗中的价值正逐渐被重视。本文回顾了大量文献，从病理及分子生物学角度总结了冷冻消融治疗胶质瘤的机制；通过众多临床病例分析了冷冻疗法的适用范围、临床疗效和存在的问题；基于国内外前瞻性研究展望了冷冻治疗胶质瘤的发展方向及前景。冷冻消融可以通过直接导致坏死和凋亡、改变局部微循环和调节抗肿瘤免疫等机制摧毁肿瘤细胞；在影像学技术实时监控下冷冻可以成为很好的手术辅助手段，现已取得了满意的临床效果；另外冷冻技术与化疗、放疗、免疫治疗等方法联合应用可更有利于发挥其治疗作用。随着冷冻设备的改进和冷冻技术的完善，冷冻消融将在胶质瘤治疗中占有重要的地位。
효질류시중추신경계통난치성종류，냉동소융치료작위일충신흥적종류치료기술재효질류치료중적개치정축점피중시。본문회고료대량문헌，종병리급분자생물학각도총결료냉동소융치료효질류적궤제；통과음다림상병례분석료냉동요법적괄용범위、림상료효화존재적문제；기우국내외전첨성연구전망료냉동치료효질류적발전방향급전경。냉동소융가이통과직접도치배사화조망、개변국부미순배화조절항종류면역등궤제최훼종류세포；재영상학기술실시감공하냉동가이성위흔호적수술보조수단，현이취득료만의적림상효과；령외냉동기술여화료、방료、면역치료등방법연합응용가경유리우발휘기치료작용。수착냉동설비적개진화냉동기술적완선，냉동소융장재효질류치료중점유중요적지위。
Glioma is one of the most refractory tumors affecting the central nervous system. As a new technique, cryoablation has been considered for the treatment of glioma. Considering previous studies, we summarized the mechanism of cryoablation to treat glioma based on pathology and molecular biology perspectives. We also analyzed the indications, effects, and problems of cryoablation in clinical practice. Furthermore, we proposed that this technique may be used in future trends and applications. The mechanism of eradicating tumor cells by cryoablation involves the following:(1) using an ultralow temperature to induce necrosis and apoptosis;(2) changing the local microcirculation of tumors;and (3) adjusting anti-tumor immunity. As an alternative surgical treatment, cryoablation could improve the therapeutic effects by real-time medical imaging. Cryoablation combined with chemotherapy, radiotherapy, immunotherapy, and other methods could provide a more effective treatment for gliomas. Therefore, cryotherapy could be a possible treatment for glioma and become a sustained research field.