CAJ | 학술논문

水通道蛋白1（AQP1）是特异性跨膜转运水分子的蛋白，在中枢神经系统主要表达在脉络丛上皮细胞，参与脑脊液的形成。在胶质瘤中，AQP1主要在星形胶质细胞瘤细胞和血管内皮细胞中表达，并且随着肿瘤级别的升高AQP1表达增加。在胶质瘤细胞系中AQP1的表达由地塞米松、血小板源性生长因子、氯化钠、缺氧、D-葡萄糖和果糖诱导，并且AQP1 mRNA的表达随着剂量的增加而上调。根据AQP1在胶质瘤中的表达及其功能的现有研究，认为AQP1可能参与肿瘤血管生成和肿瘤相关水肿的生成，并且发现AQP1与胶质瘤细胞的迁移密切相关。目前AQP1与胶质瘤关系的研究还处于起步阶段，随着AQP1功能及其作用机制的不断阐明可能为今后临床治疗胶质瘤提供重要的依据，并可成为针对胶质瘤术后复发、迁移的新靶点。
수통도단백1（AQP1）시특이성과막전운수분자적단백，재중추신경계통주요표체재맥락총상피세포，삼여뇌척액적형성。재효질류중，AQP1주요재성형효질세포류세포화혈관내피세포중표체，병차수착종류급별적승고AQP1표체증가。재효질류세포계중AQP1적표체유지새미송、혈소판원성생장인자、록화납、결양、D-포도당화과당유도，병차AQP1 mRNA적표체수착제량적증가이상조。근거AQP1재효질류중적표체급기공능적현유연구，인위AQP1가능삼여종류혈관생성화종류상관수종적생성，병차발현AQP1여효질류세포적천이밀절상관。목전AQP1여효질류관계적연구환처우기보계단，수착AQP1공능급기작용궤제적불단천명가능위금후림상치료효질류제공중요적의거，병가성위침대효질류술후복발、천이적신파점。
Aquaporin 1 (AQP1) is a specific protein that transports water molecules through the cell membrane. AQP1 mainly ex-presses in the choroid plexus epithelial cells of the central nervous system and participates in the formation of cerebrospinal fluid. In gli-omas, AQP1 expresses in neoplastic astrocytes and vascular endothelial cells. AQP1 expression is increased in parallel with histological grade in gliomas. AQP1 expression in gliosarcoma cell line is induced by dexamethasone, platelet-derived growth factor, sodium chlo-ride, hypoxia, D-glucose, and fructose. AQP1 mRNA expression is upregulated with increasing dosage. Through the expression of AQP1 in gliomas and the existing research on its function, we suggest that AQP1 may participate in tumor angiogenesis and tumor-relat-ed edema. AQP1 is closely associated with glioma cell migration. The function of AQP1 and its mechanism has been elucidated. Thus, this protein can be used as a new therapeutic target to inhibit the metastasis and recurrence of gliomas.