CAJ | 학술논문

背景：中国很多学者对不同地方做过骨质疏松症的流行病学调查，但大样本多中心的随机抽样调查仍相对缺乏，目前的文献仍不能很好地全面描述国内骨质疏松症的总体流行病学趋势。 　　目的：对中国中老年人骨质疏松流行病学的资料进行汇总，综合分析骨质疏松症流行状况。 　　方法：采用Meta分析对中国2000至2013年发表的有关中老年人骨质疏松流行病学的文献进行归纳和统计学分析。提取资料中40岁以上人群骨质疏松症的患病率，并以10岁为一个年龄组段分别进行汇总，采用stata12.0软件进行分析。 　　结果与结论：共对32篇文献进行分析，提取40岁以上人群样本总量58254例，其中男26844例，女31410例。中国40岁以上人群骨质疏松症总体患病率13.2%，其中男性11.8%，女性14.2%，差异有显著性意义(P <0.05)。随年龄增加，男性及女性的骨质疏松症患病率均逐渐增加，男性增长则相对平缓，女性进入50岁后，患病率明显增高。从Lumbar，Neck，Troch，Ward's 4个检测部位来看骨质疏松症患病率在北方地区以 Lumbar 检出率最高，可能与北方地区重体力活动相对南方地区多，加速了腰椎的退变有关。南方地区以Ward's检出率最高，有待进一步研究。男性人群中近5年的患病率较5年前明显增加，女性人群中近5年的患病率较5年前明显减小。提示中国为骨质疏松高发地区，开展骨质疏松宣传和相关疾病的防治意义重大。
배경：중국흔다학자대불동지방주과골질소송증적류행병학조사，단대양본다중심적수궤추양조사잉상대결핍，목전적문헌잉불능흔호지전면묘술국내골질소송증적총체류행병학추세。 　　목적：대중국중노년인골질소송류행병학적자료진행회총，종합분석골질소송증류행상황。 　　방법：채용Meta분석대중국2000지2013년발표적유관중노년인골질소송류행병학적문헌진행귀납화통계학분석。제취자료중40세이상인군골질소송증적환병솔，병이10세위일개년령조단분별진행회총，채용stata12.0연건진행분석。 　　결과여결론：공대32편문헌진행분석，제취40세이상인군양본총량58254례，기중남26844례，녀31410례。중국40세이상인군골질소송증총체환병솔13.2%，기중남성11.8%，녀성14.2%，차이유현저성의의(P <0.05)。수년령증가，남성급녀성적골질소송증환병솔균축점증가，남성증장칙상대평완，녀성진입50세후，환병솔명현증고。종Lumbar，Neck，Troch，Ward's 4개검측부위래간골질소송증환병솔재북방지구이 Lumbar 검출솔최고，가능여북방지구중체력활동상대남방지구다，가속료요추적퇴변유관。남방지구이Ward's검출솔최고，유대진일보연구。남성인군중근5년적환병솔교5년전명현증가，녀성인군중근5년적환병솔교5년전명현감소。제시중국위골질소송고발지구，개전골질소송선전화상관질병적방치의의중대。
BACKGROUND:Investigation regarding epidemiologic features of osteoporosis in many areas of China has been much reported. However, studies regarding large samples and multicenter in China have been rarely reported. It is said that published papers cannot give a good description about the epidemiologic features of osteoporosis at present. OBJECTIVE:To understand the epidemiologic features of osteoporosis by evaluating the data on the epidemiology of osteoporosis in the middle-aged and elderly in China. METHODS:Meta-analysis was used to evaluate the data extracted from 2000-2013 published papers on the epidemiology of prevalence rates of osteoporosis in the middle-aged and elderly in China. The prevalence rates of osteoporosis were extracted from middle-aged and elderly populations aged above 40 years, with 10 years for a group. The studies were col ected and analyzed using Stata 12.0. RESULTS AND CONCLUSION:Thirty two articles were included with a total of 58 254 people (26 844 males and 31 410 females). The total prevalence rate of osteoporosis at the age above 40 years in China was 13.2%. The prevalence rate of males was 11.8%and that of females was 14.2%, and there was a significant difference between males and females (P<0.05). With aging, the prevalence rate of osteoporosis is increasing both in males and females, which increases gradual y in males but significantly elevates in females over 50 years old. In China, the detection rate of lumbar osteoporosis is higher in the northern region than the southern region, probably because of more heavy physical activities in the northern region;whereas, the detection rate of Ward’s osteoporosis is higher in the southern region than the northern region. In the recent 5 years, the prevalence rate of osteoporosis is significant increased in males and reduced in females compared with 5 years ago. These findings suggest that osteoporosis in Chinese is common and extensively distributed, and it is important to propagate knowledge of osteoporosis and prevent osteoporosis.