CAJ | 학술논문

特应性皮炎是一种慢性复发性炎症性皮肤病,具有血清IgE水平升高、Th2型免疫过度反应以及对多种病原微生物易感性增加等特点.研究表明,朗格汉斯细胞和表皮炎症样树突细胞是在特应性皮炎皮损中出现的两种树突细胞.其中表皮炎症样树突细胞是炎症性皮肤病所特有的一种树突细胞,仅在炎症性皮肤中表达,被激活后可释放大量炎症因子和趋化因子,而在皮炎得到成功控制后逐步消失.在特应性皮炎的病理生理机制中,表皮炎症样树突细胞不仅在炎症的持续和发展中起着重要作用,还可能与皮损局部Th2反应向Thl反应漂移有关.
특응성피염시일충만성복발성염증성피부병,구유혈청IgE수평승고、Th2형면역과도반응이급대다충병원미생물역감성증가등특점.연구표명,랑격한사세포화표피염증양수돌세포시재특응성피염피손중출현적량충수돌세포.기중표피염증양수돌세포시염증성피부병소특유적일충수돌세포,부재염증성피부중표체,피격활후가석방대량염증인자화추화인자,이재피염득도성공공제후축보소실.재특응성피염적병리생리궤제중,표피염증양수돌세포불부재염증적지속화발전중기착중요작용,환가능여피손국부Th2반응향Thl반응표이유관.
Atopic dermatitis (AD) is a chronic,recurrent and inflammatory skin disease characterized by increased serum IgE levels,predominance of T-helper cell type 2 (Th2) immune response,and elevated susceptibility to various pathogenic microorganisms.Studies have shown that there are two kinds of dendritic cells,including inflammatory dendritic epidermal cells (IDECs) and Langerhans cells,in AD lesions.IDECs specifically exist in inflammatory skin disease,and are exclusively expressed in inflamed skin.Moreover,activated IDECs may release various inflammatory cytokines and chemotactic factors,and gradually disappear after the control of dermatitis.In the pathophysiology of atopic dermatitis,IDECs not only play important roles in the maintenance and progression of inflammation,but also are associated with the shift from Th2 to Th1 immune response in skin lesions of atopic dermatitis.