中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
7期
1109-1114
,共6页
组织构建%组织工程%细胞骨架%力学信号%Rho家族蛋白%蛋白激酶C%整合素%丝裂原激活蛋白激酶%信号通路%生物功能%广东省自然科学基金
組織構建%組織工程%細胞骨架%力學信號%Rho傢族蛋白%蛋白激酶C%整閤素%絲裂原激活蛋白激酶%信號通路%生物功能%廣東省自然科學基金
조직구건%조직공정%세포골가%역학신호%Rho가족단백%단백격매C%정합소%사렬원격활단백격매%신호통로%생물공능%광동성자연과학기금
cytoskeleton%signal transduction%Rho-associated kinases%protein kinase C%integrins%mitogen-activated protein kinases
背景：细胞在感受力学刺激后，通过一定的信号转导机制，将力学信号转换成化学信号，进而实现其生物功能。在这一系列的信号转导过程中，横贯细胞的细胞骨架作为枢纽，发挥着重要作用。<br> 目的：通过系统的分析和总结细胞骨架在力学信号转导通路中的作用机制，为细胞骨架相关疾病的临床治疗提供潜在的治疗靶点。<br> 方法：以英文检索词为“cytoskeleton，microtubules，microfilaments，intermediate filaments，mechanical stimulation，signal transduction ”及中文检索词为“细胞骨架、微管、微丝、中间纤维丝、机械刺激、信号传导”，由第一作者检索1990至2012年PubMed 数据库及中国知网中文科技数据库，查阅近年机械刺激对细胞骨架影响的相关文献，最终保留48篇文献。<br> 结果与结论：机械刺激是细胞增殖、生长发育以及凋亡的重要因素。随着对细胞骨架认识的逐渐深入，人们发现细胞骨架在细胞对力学刺激的感受和信息传导的过程中起重要作用。机械刺激作用于细胞后，通过 Rho家族蛋白、蛋白激酶C、整合素以及丝裂原激活蛋白激酶等多条信号通路，且各种信号传导通路中存在交联，从而影响细胞骨架的重组，并将力学刺激进一步转换成化学信号，最终完成其生物效应。
揹景：細胞在感受力學刺激後，通過一定的信號轉導機製，將力學信號轉換成化學信號，進而實現其生物功能。在這一繫列的信號轉導過程中，橫貫細胞的細胞骨架作為樞紐，髮揮著重要作用。<br> 目的：通過繫統的分析和總結細胞骨架在力學信號轉導通路中的作用機製，為細胞骨架相關疾病的臨床治療提供潛在的治療靶點。<br> 方法：以英文檢索詞為“cytoskeleton，microtubules，microfilaments，intermediate filaments，mechanical stimulation，signal transduction ”及中文檢索詞為“細胞骨架、微管、微絲、中間纖維絲、機械刺激、信號傳導”，由第一作者檢索1990至2012年PubMed 數據庫及中國知網中文科技數據庫，查閱近年機械刺激對細胞骨架影響的相關文獻，最終保留48篇文獻。<br> 結果與結論：機械刺激是細胞增殖、生長髮育以及凋亡的重要因素。隨著對細胞骨架認識的逐漸深入，人們髮現細胞骨架在細胞對力學刺激的感受和信息傳導的過程中起重要作用。機械刺激作用于細胞後，通過 Rho傢族蛋白、蛋白激酶C、整閤素以及絲裂原激活蛋白激酶等多條信號通路，且各種信號傳導通路中存在交聯，從而影響細胞骨架的重組，併將力學刺激進一步轉換成化學信號，最終完成其生物效應。
배경：세포재감수역학자격후，통과일정적신호전도궤제，장역학신호전환성화학신호，진이실현기생물공능。재저일계렬적신호전도과정중，횡관세포적세포골가작위추뉴，발휘착중요작용。<br> 목적：통과계통적분석화총결세포골가재역학신호전도통로중적작용궤제，위세포골가상관질병적림상치료제공잠재적치료파점。<br> 방법：이영문검색사위“cytoskeleton，microtubules，microfilaments，intermediate filaments，mechanical stimulation，signal transduction ”급중문검색사위“세포골가、미관、미사、중간섬유사、궤계자격、신호전도”，유제일작자검색1990지2012년PubMed 수거고급중국지망중문과기수거고，사열근년궤계자격대세포골가영향적상관문헌，최종보류48편문헌。<br> 결과여결론：궤계자격시세포증식、생장발육이급조망적중요인소。수착대세포골가인식적축점심입，인문발현세포골가재세포대역학자격적감수화신식전도적과정중기중요작용。궤계자격작용우세포후，통과 Rho가족단백、단백격매C、정합소이급사렬원격활단백격매등다조신호통로，차각충신호전도통로중존재교련，종이영향세포골가적중조，병장역학자격진일보전환성화학신호，최종완성기생물효응。
BACKGROUND:cells under mechanical stimulation can achieve their biological functions by converting mechanical signals into chemical signals through certain signal transduction mechanism. As the fibrous framework throughout a cell, cytoskeleton is one of the critical components in this process. <br> OBJECTIVE:Through systemical y analyzing the role of the cytoskeleton in mechanical signal transduction, to provide a potential therapeutic target for the clinical treatment of cytoskeleton related diseases. <br> METHODS:In order to search relevant articles about the mechanics mechanism of signal transduction of cytoskeleton from PubMed and CNKI databases (from 1990 to 2012), a computer-based search was performed, using the key words of“cytoskeleton, microtubules, microfilaments, intermediate filaments, mechanical stimulation, signal transduction”in English and Chinese, respectively. After eliminating literatures which were irrelevant to research purpose or containing a similar content, 48 articles were chosen for further analysis. <br> RESULTS AND CONCLUSION:Mechanical stimulation plays an important role in cellproliferation, development and apoptosis. With the gradual understanding of the biological function of cytoskeleton, people have found that cytoskeleton is one of the critical components in the process of the mechanical signal transduction. After getting mechanical stimulation, cytoskeleton can be reorganized through Rho, protein kinase C, integrin and mitogen-activated protein kinase signaling pathways, then converting the mechanical stimulation to chemical signals and finishing its biological functions final y.
