中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
7期
1094-1100
,共7页
组织构建%软骨组织工程%关节软骨%组织工程学%细胞来源%软骨细胞%干细胞%信号分子%生物学效应%转染%机械载荷%支架%国家自然科学基金
組織構建%軟骨組織工程%關節軟骨%組織工程學%細胞來源%軟骨細胞%榦細胞%信號分子%生物學效應%轉染%機械載荷%支架%國傢自然科學基金
조직구건%연골조직공정%관절연골%조직공정학%세포래원%연골세포%간세포%신호분자%생물학효응%전염%궤계재하%지가%국가자연과학기금
cartilage,articular%chondrocytes%tissue engineering%cytokines%cytoskeleton
背景：由于关节软骨的组织再生能力非常低，因此创伤或退变疾病导致软骨缺损很难实现自身修复。
<br> 目的：通过资料分析了解关节软骨组织工程学的研究现状。
<br> 方法：以“Articular cartilage, Tissue engineering, Signaling molecules, Scaffolds”为英文检索词，“关节软骨，组织工程学，细胞来源，信号分子，支架”为中文检索词，检索 Pubmed 数据库、CNKI 数据库2000至2013年发表的相关文献。共检索到202篇文献，排除无关重复的文献，保留70篇进行综述。
<br> 结果与结论：软骨细胞和干细胞是当前软骨组织工程研究的主要细胞来源。多种细胞因子、激素类物质及生长因子会影响软骨细胞的合成及分解代谢过程。新型生物材料支架可为细胞提供一个适宜的环境，刺激细胞软骨基质合成，临时替代天然软骨基质的功能，直至新生软骨形成。而随着研究的不断深入，组织工程学关节软骨必将表现出良好的应用前景。
揹景：由于關節軟骨的組織再生能力非常低，因此創傷或退變疾病導緻軟骨缺損很難實現自身脩複。
<br> 目的：通過資料分析瞭解關節軟骨組織工程學的研究現狀。
<br> 方法：以“Articular cartilage, Tissue engineering, Signaling molecules, Scaffolds”為英文檢索詞，“關節軟骨，組織工程學，細胞來源，信號分子，支架”為中文檢索詞，檢索 Pubmed 數據庫、CNKI 數據庫2000至2013年髮錶的相關文獻。共檢索到202篇文獻，排除無關重複的文獻，保留70篇進行綜述。
<br> 結果與結論：軟骨細胞和榦細胞是噹前軟骨組織工程研究的主要細胞來源。多種細胞因子、激素類物質及生長因子會影響軟骨細胞的閤成及分解代謝過程。新型生物材料支架可為細胞提供一箇適宜的環境，刺激細胞軟骨基質閤成，臨時替代天然軟骨基質的功能，直至新生軟骨形成。而隨著研究的不斷深入，組織工程學關節軟骨必將錶現齣良好的應用前景。
배경：유우관절연골적조직재생능력비상저，인차창상혹퇴변질병도치연골결손흔난실현자신수복。
<br> 목적：통과자료분석료해관절연골조직공정학적연구현상。
<br> 방법：이“Articular cartilage, Tissue engineering, Signaling molecules, Scaffolds”위영문검색사，“관절연골，조직공정학，세포래원，신호분자，지가”위중문검색사，검색 Pubmed 수거고、CNKI 수거고2000지2013년발표적상관문헌。공검색도202편문헌，배제무관중복적문헌，보류70편진행종술。
<br> 결과여결론：연골세포화간세포시당전연골조직공정연구적주요세포래원。다충세포인자、격소류물질급생장인자회영향연골세포적합성급분해대사과정。신형생물재료지가가위세포제공일개괄의적배경，자격세포연골기질합성，림시체대천연연골기질적공능，직지신생연골형성。이수착연구적불단심입，조직공정학관절연골필장표현출량호적응용전경。
BACKGROUND:Because the tissue regeneration capacity of articular cartilage is very low, the cartilage defects induced by joint injuries or degenerative diseases are hard to do their own repair.
<br> OBJECTIVE:To comprehend the current status of tissue engineering of articular cartilage by analyzing data.
<br> METHODS:The PubMed database and CNKI database from 2000 to 2013 were retrieved using computer with the key words of“articular cartilage, tissue engineering, signaling molecules, scaffolds”in English and“articular cartilage, tissue engineering, cellsource, signaling molecules, scaffolds”in Chinese. A total of 202 literatures were screened out, and the repetitive and irrelevant researches were eliminated. Final y, 70 literatures were included for review.
<br> RESULTS AND CONCLUSION:The most investigated cellsources for their potential in cartilage tissue engineering are chondrocytes and stem cells. Several cytokines, hormones and growth factors are known to influence the synthesis, anabolic and catabolic processes by chondrocytes. New biomaterial scaffolds in cartilage tissue engineering provide a comfortable niche for cells, where cells were stimulated to synthesize cartilage matrix, and to temporarily replace the function of the native matrix until new cartilage had formed. With the deepening of the researches, tissue engineering articular cartilage wil exhibit good prospects.
