中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
7期
1088-1093
,共6页
组织构建%骨髓细胞%干细胞%间充质干细胞%半月板%支架%组织工程%损伤%修复
組織構建%骨髓細胞%榦細胞%間充質榦細胞%半月闆%支架%組織工程%損傷%脩複
조직구건%골수세포%간세포%간충질간세포%반월판%지가%조직공정%손상%수복
stem cells%mesenchymal stem cells%menisci,tibial%stents%tissue engineering
背景：半月板损伤常规治疗手段效果并不显著，随着组织工程学的进展，间充质干细胞-支架复合体有望应用于此方面的治疗。<br> 目的：对间充质干细胞-支架技术治疗半月板损伤的相关研究进行综述，为后续研究和临床应用提供参考。<br> 方法：第一、二作者共同检索PubMed、中国期刊全文数据库(CNKI)、维普数据库和万方数据库1980至2013年有关间充质干细胞-支架复合体修复半月板损伤的文献，英文检索词为“mesenchymal stem cel ，meniscus injury，tissue engineering，scaffold，stent”，中文检索词为“间充质干细胞，半月板损伤，组织工程”。同一领域文献选择近期发表或发表在权威杂志的文章，排除Meta分析及重复性研究。共检索到文献282篇，根据纳入标准选取59篇文献进行综述。<br> 结果与结论：目前很多研究表明间充质干细胞可在体外或体内被诱导分化为软骨细胞，间充质-支架复合体对半月板损伤有明显疗效。虽然此技术仍处于探索阶段，但其具有取材方便，无抗原性，有生命力等优点，在治疗半月板损伤方面有着广阔的应用前景。
揹景：半月闆損傷常規治療手段效果併不顯著，隨著組織工程學的進展，間充質榦細胞-支架複閤體有望應用于此方麵的治療。<br> 目的：對間充質榦細胞-支架技術治療半月闆損傷的相關研究進行綜述，為後續研究和臨床應用提供參攷。<br> 方法：第一、二作者共同檢索PubMed、中國期刊全文數據庫(CNKI)、維普數據庫和萬方數據庫1980至2013年有關間充質榦細胞-支架複閤體脩複半月闆損傷的文獻，英文檢索詞為“mesenchymal stem cel ，meniscus injury，tissue engineering，scaffold，stent”，中文檢索詞為“間充質榦細胞，半月闆損傷，組織工程”。同一領域文獻選擇近期髮錶或髮錶在權威雜誌的文章，排除Meta分析及重複性研究。共檢索到文獻282篇，根據納入標準選取59篇文獻進行綜述。<br> 結果與結論：目前很多研究錶明間充質榦細胞可在體外或體內被誘導分化為軟骨細胞，間充質-支架複閤體對半月闆損傷有明顯療效。雖然此技術仍處于探索階段，但其具有取材方便，無抗原性，有生命力等優點，在治療半月闆損傷方麵有著廣闊的應用前景。
배경：반월판손상상규치료수단효과병불현저，수착조직공정학적진전，간충질간세포-지가복합체유망응용우차방면적치료。<br> 목적：대간충질간세포-지가기술치료반월판손상적상관연구진행종술，위후속연구화림상응용제공삼고。<br> 방법：제일、이작자공동검색PubMed、중국기간전문수거고(CNKI)、유보수거고화만방수거고1980지2013년유관간충질간세포-지가복합체수복반월판손상적문헌，영문검색사위“mesenchymal stem cel ，meniscus injury，tissue engineering，scaffold，stent”，중문검색사위“간충질간세포，반월판손상，조직공정”。동일영역문헌선택근기발표혹발표재권위잡지적문장，배제Meta분석급중복성연구。공검색도문헌282편，근거납입표준선취59편문헌진행종술。<br> 결과여결론：목전흔다연구표명간충질간세포가재체외혹체내피유도분화위연골세포，간충질-지가복합체대반월판손상유명현료효。수연차기술잉처우탐색계단，단기구유취재방편，무항원성，유생명력등우점，재치료반월판손상방면유착엄활적응용전경。
BACKGROUND:Meniscus injury is a common disease, whose curative effect is not obvious. The clinical application of tissue engineering technology is gradual y rising, and mesenchymal stem cells-stents complex is expected to be used for the treatment of meniscus injury. <br> OBJECTIVE:To review the application process of mesenchymal stem cells-stents complex in meniscus injury, in order to provide reference for further study and clinical practice. <br> METHODS:A computer-based online search of PubMed database, VIP database, Wanfang database and China National Knowledge Infrastructure between 1980 and 2013 was performed to search related articles on mesenchymal stem cells-stents complex in meniscus injury. The key words were“mesenchymal stem cell, meniscus injury, tissue engineering, scaffold, stent”in English and“mesenchymal stem cell, meniscus injury, tissue engineering”in Chinese. For the articles in the same field, we preferred the ones published recently or in authorize journals. Meta-analysis and repetitive studies were excluded. 282 articles were included, and final y 59 articles were included according to inclusion criteria. <br> RESULTS AND CONCLUSION:Nowadays, numerous experiments showed that mesenchymal stem cells could differentiate into chondrocytes both in vivo or vitro. Mesenchymal stem cells-stents complex could be effective to meniscus injury. Although this technique is stil in exploratory stage, it has promising application prospects in treatment of meniscus injury, because it is characterized by convenience to col ect samples, vitality and no antigenicity.
