贵州医药
貴州醫藥
귀주의약
GUIZHOU MEDICAL JOURNAL
2014年
6期
491-494
,共4页
全基因组关联研究%单核苷酸多态性%文献研究
全基因組關聯研究%單覈苷痠多態性%文獻研究
전기인조관련연구%단핵감산다태성%문헌연구
Words Genome-wide association study (GWAS)%Single nucleotide polymorphisms%Literature research
目的：分析宫颈癌、子宫内膜癌和卵巢癌全基因组关联研究（Genome-wide associa-tion study ，GWAS ）英文文献的数据构成特征。方法对国际最新GWAS研究数据库之一---美国国立人类基因组研究所（National Human Genome Research Institute ，NHGRI）数据库进行数据挖掘。结果运用文献计量学方法客观分析了N HGRI的文献基本特征、第一、二阶段样本量、染色体区域相关SNP、对照组相关风险等位基因频率、P值文献中最强单核苷酸多态性（Single Nucleotide Polymor-phisms ，SNP）、优势比（odds ratio ，OR）或β相关系数和实验平台及检测SNP数量8项数据，找出了妇科肿瘤GWAS的一些共性特征。结论17号染色体区域SNP多态性可能是妇科肿瘤遗传易感区域，深入此易感区域研究可能为阐述肿瘤发生治疗和评估预后提供一定线索。
目的：分析宮頸癌、子宮內膜癌和卵巢癌全基因組關聯研究（Genome-wide associa-tion study ，GWAS ）英文文獻的數據構成特徵。方法對國際最新GWAS研究數據庫之一---美國國立人類基因組研究所（National Human Genome Research Institute ，NHGRI）數據庫進行數據挖掘。結果運用文獻計量學方法客觀分析瞭N HGRI的文獻基本特徵、第一、二階段樣本量、染色體區域相關SNP、對照組相關風險等位基因頻率、P值文獻中最彊單覈苷痠多態性（Single Nucleotide Polymor-phisms ，SNP）、優勢比（odds ratio ，OR）或β相關繫數和實驗平檯及檢測SNP數量8項數據，找齣瞭婦科腫瘤GWAS的一些共性特徵。結論17號染色體區域SNP多態性可能是婦科腫瘤遺傳易感區域，深入此易感區域研究可能為闡述腫瘤髮生治療和評估預後提供一定線索。
목적：분석궁경암、자궁내막암화란소암전기인조관련연구（Genome-wide associa-tion study ，GWAS ）영문문헌적수거구성특정。방법대국제최신GWAS연구수거고지일---미국국립인류기인조연구소（National Human Genome Research Institute ，NHGRI）수거고진행수거알굴。결과운용문헌계량학방법객관분석료N HGRI적문헌기본특정、제일、이계단양본량、염색체구역상관SNP、대조조상관풍험등위기인빈솔、P치문헌중최강단핵감산다태성（Single Nucleotide Polymor-phisms ，SNP）、우세비（odds ratio ，OR）혹β상관계수화실험평태급검측SNP수량8항수거，조출료부과종류GWAS적일사공성특정。결론17호염색체구역SNP다태성가능시부과종류유전역감구역，심입차역감구역연구가능위천술종류발생치료화평고예후제공일정선색。
Objective To analyze the data constitution features of genome-wide association studies (GWAS) for the cervical cancer ,endomentrial cancer and ovarian cancer in English literature .Methods National Human Genome Institute GWAS database ,one of the latest international research database of GWAS ,was meticulously data mined .Results Using literature metrology method objectively analyzed eight data of the N HGRI’s basic characteristics of the literature ,the first and second stage of sample size ,chromosomal regions associated SNPS ,related risk allele frequency in the control group ,P value with the strongest SNP in the literature ,odds ratio or beta coefficient of correlation and experimental platform including testing the SNP number ,and found out the common characteristics of the gynaeco-logical tumor GWAS .Conclusion Chromosome 17 regional SNP polymorphism may be the gynaecolog-ical tumor genetic susceptibility region ,and through into the susceptible area can provide some clues in the treatment of cancer and prognosis assessment .
