CAJ | 학술논문

目的：观察自体外周血干细胞移植治疗乙型肝炎肝硬化失代偿期患者的疗效。方法：将58例乙型肝炎肝硬化失代偿期患者随机分为观察组38例和对照组20例。对照组予以基础治疗，观察组在基础治疗上行自体外周血干细胞移植治疗并随访24周，观察两组患者治疗前后血清白蛋白（ALB）、总胆红素（TBIL）、凝血酶原时间（PT）以及临床症状的变化。结果：对照组治疗后各时间段患者ALB、TBIL和PT水平与治疗前比较差异无统计学意义。与观察组治疗前比较，观察组患者治疗后12周和24周血清中ALB水平显著上升，TBIL和PT 显著降低。观察组治疗后12周和24周各指标与对照组比较具有统计学差异。治疗8周后，对照组患者腹胀、食欲、乏困和腹水的改善率分别为50．00％、40．00％、55．00％和50．00％，观察组改善率分别为84．21％、78．95％、86．84％和92．00％，两组患者在腹胀、食欲、乏困和腹水的改善或减轻方面具有统计学差异。结论：自体外周血干细胞移植治疗失代偿期肝硬化安全、有效、副作用小，可作为肝硬化患者临床治疗方案。
목적：관찰자체외주혈간세포이식치료을형간염간경화실대상기환자적료효。방법：장58례을형간염간경화실대상기환자수궤분위관찰조38례화대조조20례。대조조여이기출치료，관찰조재기출치료상행자체외주혈간세포이식치료병수방24주，관찰량조환자치료전후혈청백단백（ALB）、총담홍소（TBIL）、응혈매원시간（PT）이급림상증상적변화。결과：대조조치료후각시간단환자ALB、TBIL화PT수평여치료전비교차이무통계학의의。여관찰조치료전비교，관찰조환자치료후12주화24주혈청중ALB수평현저상승，TBIL화PT 현저강저。관찰조치료후12주화24주각지표여대조조비교구유통계학차이。치료8주후，대조조환자복창、식욕、핍곤화복수적개선솔분별위50．00％、40．00％、55．00％화50．00％，관찰조개선솔분별위84．21％、78．95％、86．84％화92．00％，량조환자재복창、식욕、핍곤화복수적개선혹감경방면구유통계학차이。결론：자체외주혈간세포이식치료실대상기간경화안전、유효、부작용소，가작위간경화환자림상치료방안。
Objective :To observe the efficacy of autologous peripheral blood stem cell transplantation treating patients with decompensated hepatitis B liver cirrhosis .Methods :58 patients with decompensated hepatitis B liver cirrhosis were randomly divided into observation group (n=38) and control group(n=20) .The control group were given basic treatment ,the observation group were treated with autologous peripheral blood stem cell transplan-tation and followed twenty-four weeks ,the changs of serum albumin(ALB) ,total bilirubin(TBIL) ,prothrombin time(PT ) and clinical symptoms were observed before and after treatment .Results :The levels of ALB、TBIL and PT in control group after treatment had no statistical difference compared with pro-treatment .Comapred with pro-treatment ,the level of ALB in observation group increased significantly after treated twelve weeks and twenty-four weeks while the level of TBIL and PT decreased significantly .All indexes after treated twelve weeks and twenty-four weeks had statistical difference between contol group and observation group .The improved rate of bloating ,appe-tite ,fatigue and ascites were 50 .00% 、40 .00% 、55 .00% and 50 .00% respectively after treated for eight weeks ,the observation group were 84 .21% 、78 .95% 、86 .84% and 92 .00% respectively ,the two groups had statistical differ-ence on the improvement of bloating ,appetite ,fatigue and ascites .Conclusion:Autologous peripheral blood stem cell transplantation treating for patients with decompensated hepatitis B liver cirrhosis is safe ,effective and has little side effects ,it can be used as clinical treatment for patients with hepatitis B liver cirrhosis .