CAJ | 학술논문

目的：探讨子宫内膜微腺体癌（microglandular adenocarcinoma，MGA）的临床及病理组织学特征、诊断。方法观察2例微腺体癌的临床及病理学特征，行免疫组织化学染色，同时复习相关文献。结果2例微腺体癌发病年龄分别为58岁及69岁，以阴道不规律流血就诊，2例活检标本均为微腺体癌，其中1例手术切除标本合并高分化子宫内膜样腺癌。镜下可见标本主要由形态不规则、紧密排列的小腺体构成，细胞核呈轻度不典型。核分裂像少见。腺体间内膜间质少见，见泡沫细胞及大量炎细胞。主要免疫表型：2例上皮均呈 P16核（＋）、Vim弥漫（＋）、Ki-67（10％＋）、间质细胞 CD10（＋）、CD34（-）。结论微腺体癌是一种少见的宫内膜黏液腺癌，恶性程度低，预后较好，通过免疫组织化学染色及组织学形态学特点与宫颈黏膜的微腺体增生（microglandular hyper-plasia，MGH）、宫颈粘液腺癌鉴别。
목적：탐토자궁내막미선체암（microglandular adenocarcinoma，MGA）적림상급병리조직학특정、진단。방법관찰2례미선체암적림상급병이학특정，행면역조직화학염색，동시복습상관문헌。결과2례미선체암발병년령분별위58세급69세，이음도불규률류혈취진，2례활검표본균위미선체암，기중1례수술절제표본합병고분화자궁내막양선암。경하가견표본주요유형태불규칙、긴밀배렬적소선체구성，세포핵정경도불전형。핵분렬상소견。선체간내막간질소견，견포말세포급대량염세포。주요면역표형：2례상피균정 P16핵（＋）、Vim미만（＋）、Ki-67（10％＋）、간질세포 CD10（＋）、CD34（-）。결론미선체암시일충소견적궁내막점액선암，악성정도저，예후교호，통과면역조직화학염색급조직학형태학특점여궁경점막적미선체증생（microglandular hyper-plasia，MGH）、궁경점액선암감별。
Objective To investigate clinical and histopathological features,dignosis and differential diagno-sis of the endometrium microglandular carcinoma (MGA).Methods The clinical and pathological features of microglandular carcinoma in 2 patients were observed.Immunohistochemical staining and literature re-view were also used.Results In 2 cases,the average age of micro gland carcinoma is 63.5 years.Clinical manifestation is vaginal irregular bleeding.Both cases are diagnosed as microglandular carcinoma by biopsy.One of the cases had a combined well differentiated uterine endometrioid carcinoma.Endoscope is mainly composed of irregular shape,closely spaced small glands,and glandular cells is mild atypical.Mi-tosis is rarely observed.The endometrial stromal between glands is rare,but foam cells and Inflammatory cells are much observed.The main immune phenotype:in 2 cases were P16 nuclear (+),Vim diffuse (+),Ki-67 (10% +),interstitial cells :CD10 (+),CD34 (-).Conclusion The micro gland carcinoma is a rare endometrial adenocarcinoma.It is low malignant,and prognosis is good.It can be differentiated from cervical microglandular hyperplasia (MGH)and cervical mucus gland carcinoma by immunohisto-chemistry and morphological characteristics.