安徽医科大学学报
安徽醫科大學學報
안휘의과대학학보
ACTA UNIVERSITY MEDICINALIS ANHUI
2014年
7期
1013-1015
,共3页
手足口病%柯萨奇病毒A组16型%肠道病毒71型%IgG%IgM%流行病学
手足口病%柯薩奇病毒A組16型%腸道病毒71型%IgG%IgM%流行病學
수족구병%가살기병독A조16형%장도병독71형%IgG%IgM%류행병학
HFMD%CoxA16%EV71%IgG%IgM%epidemiology
采用ELISA法检测0~14岁人群柯萨奇病毒A组16型(CoxA16)及肠道病毒71型(EV71)抗体水平。在入选的1000例儿童中,EV71 IgM总阳性率19．9%,EV71 IgG总阳性率47.7%,CoxA16 IgM总阳性率22．8%,CoxA16 IgG总阳性率51．3%；EV71 IgM总阳性率与CoxA16 IgM总阳性率比较,差异无统计学意义(χ2=2．794,P>0．05)；EV71 IgG总阳性率与CoxA16 IgG总阳性率比较,差异无统计学意义(χ2=2．793,P>0．05)。各年龄组比较,新生儿组IgG抗体阳性率较高,其EV71 IgG抗体阳性率41．5%,CoxA16 IgG抗体阳性率49．5%；婴儿组IgG抗体阳性率最低,EV71 IgG、CoxA16 IgG抗体阳性率分别为38．0%,43．5%；除新生儿组外,随年龄增加,人群EV71、CoxA16 IgG逐渐增高,组间差异有统计学意义(χ2=27．04、19．98, P <0．01)；在 IgM 方面,人群EV71、CoxA16 IgM 随年龄逐渐升高,组间差异有统计学意义(χ2=41．12、37．13,P<0．01)。两种HFMD病原体的IgM、IgG抗体性别间差异无统计学意义(χ2=0．51、1．77、0．36、2．12,P>0．05)。
採用ELISA法檢測0~14歲人群柯薩奇病毒A組16型(CoxA16)及腸道病毒71型(EV71)抗體水平。在入選的1000例兒童中,EV71 IgM總暘性率19．9%,EV71 IgG總暘性率47.7%,CoxA16 IgM總暘性率22．8%,CoxA16 IgG總暘性率51．3%；EV71 IgM總暘性率與CoxA16 IgM總暘性率比較,差異無統計學意義(χ2=2．794,P>0．05)；EV71 IgG總暘性率與CoxA16 IgG總暘性率比較,差異無統計學意義(χ2=2．793,P>0．05)。各年齡組比較,新生兒組IgG抗體暘性率較高,其EV71 IgG抗體暘性率41．5%,CoxA16 IgG抗體暘性率49．5%；嬰兒組IgG抗體暘性率最低,EV71 IgG、CoxA16 IgG抗體暘性率分彆為38．0%,43．5%；除新生兒組外,隨年齡增加,人群EV71、CoxA16 IgG逐漸增高,組間差異有統計學意義(χ2=27．04、19．98, P <0．01)；在 IgM 方麵,人群EV71、CoxA16 IgM 隨年齡逐漸升高,組間差異有統計學意義(χ2=41．12、37．13,P<0．01)。兩種HFMD病原體的IgM、IgG抗體性彆間差異無統計學意義(χ2=0．51、1．77、0．36、2．12,P>0．05)。
채용ELISA법검측0~14세인군가살기병독A조16형(CoxA16)급장도병독71형(EV71)항체수평。재입선적1000례인동중,EV71 IgM총양성솔19．9%,EV71 IgG총양성솔47.7%,CoxA16 IgM총양성솔22．8%,CoxA16 IgG총양성솔51．3%；EV71 IgM총양성솔여CoxA16 IgM총양성솔비교,차이무통계학의의(χ2=2．794,P>0．05)；EV71 IgG총양성솔여CoxA16 IgG총양성솔비교,차이무통계학의의(χ2=2．793,P>0．05)。각년령조비교,신생인조IgG항체양성솔교고,기EV71 IgG항체양성솔41．5%,CoxA16 IgG항체양성솔49．5%；영인조IgG항체양성솔최저,EV71 IgG、CoxA16 IgG항체양성솔분별위38．0%,43．5%；제신생인조외,수년령증가,인군EV71、CoxA16 IgG축점증고,조간차이유통계학의의(χ2=27．04、19．98, P <0．01)；재 IgM 방면,인군EV71、CoxA16 IgM 수년령축점승고,조간차이유통계학의의(χ2=41．12、37．13,P<0．01)。량충HFMD병원체적IgM、IgG항체성별간차이무통계학의의(χ2=0．51、1．77、0．36、2．12,P>0．05)。
Enzyme-linked immunosorbent assay ( ELISA) was applied to detect the antibody against CoxA16 and EV71 among 0~14 age groups. In 1 000 cases of children, the total positive rate of anti-EV71 IgM was 19. 9%, the total positive rate of anti-EV71 IgG was 47. 7%, the total positive rate of anti-CoxA16 IgM was 22. 8%, the to-tal positive rate of anti-CoxA16 IgG was 51. 3%. There was a negative correlation between positivity for EV71 IgM and positivity for CoxA16 IgM(χ2 =2. 794,P>0. 05). There was also a negative correlation between positivity for EV71 IgG and positivity for CoxA16 IgG(χ2 =2. 793,P>0. 05). The positive rate of IgG antibody against CoxA16 and EV71 was higher in neonatal group in which anti-EV71 IgG was 41 . 5% and anti-CoxA16 IgG was 49 . 5%. The lowest positive rate of IgG antibody against CoxA16 and EV71 was in infant group in which anti-EV71 IgG was 38. 0% and anti-CoxA16 IgG was 43. 5%. Except for neonatal group,the positive rate of IgG antibody against Cox-A16 and EV71 increased gradually with the age growth, there were statistical differences among the age groups (χ2=27. 04 and 19. 98,P<0. 01). With the age growth,the positive rate of IgM antibody against EV71 and CoxA16 increased,there were statistical differences among the age groups(χ2 =41. 12 and 37. 13,P<0. 01). There were not statistical differences between gender groups (χ2 =0. 51,1. 77,0. 36 and 2. 12,P>0. 05).
