CAJ | 학술논문

目的：比较3种门冬胰岛素30联合用药方案的疗效、安全性和经济性指标，优化2型糖尿病患者治疗方案。方法：将2型糖尿病患者随机分为3组，A组：门冬胰岛素30注射液每日2次，联合二甲双胍片治疗；B组：门冬胰岛素30注射液每日3次，联合二甲双胍片治疗；C组：门冬胰岛素30注射液每日2次，联合二甲双胍片和阿卡波糖片治疗。收集疗效及安全性数据，进行统计学分析。结果：3种方案控制患者血糖效果理想，疗效和安全性相似，组间无显著性差异；但3组间每日胰岛素用量有极显著性差异(F=11.06，P<0.01)，每日抗糖尿病药物费用差别亦有统计学意义(F=82.28，P<0.01)。结论： B组方案(门冬胰岛素30注射液每日3次，联合二甲双胍片)，每日抗糖尿病药物费用和胰岛素用量最低，更符合药物经济学的最小成本原则，值得临床广泛应用。
목적：비교3충문동이도소30연합용약방안적료효、안전성화경제성지표，우화2형당뇨병환자치료방안。방법：장2형당뇨병환자수궤분위3조，A조：문동이도소30주사액매일2차，연합이갑쌍고편치료；B조：문동이도소30주사액매일3차，연합이갑쌍고편치료；C조：문동이도소30주사액매일2차，연합이갑쌍고편화아잡파당편치료。수집료효급안전성수거，진행통계학분석。결과：3충방안공제환자혈당효과이상，료효화안전성상사，조간무현저성차이；단3조간매일이도소용량유겁현저성차이(F=11.06，P<0.01)，매일항당뇨병약물비용차별역유통계학의의(F=82.28，P<0.01)。결론： B조방안(문동이도소30주사액매일3차，연합이갑쌍고편)，매일항당뇨병약물비용화이도소용량최저，경부합약물경제학적최소성본원칙，치득림상엄범응용。
Objective: To compare the efficacy, safety and economic indicators of three combination therapy scheme in type 2 diabetes subjects, and to find out the best treatment scheme. Methods: The subjects with type 2 diabetes were divided into 3 groups randomly. The efficacy, safety and economic data were colected and analyzed. Results: The blood glucose concentration of three groups al dropped obviously. Efficacy and safety were similar in 3 groups.There were significant differences among the three groups in insulin doses(F=11.06, P<0.01) and daily anti-diabetic drug costs (F=82.28,P<0.01). Conclusion: The treatment scheme B (twice-daily insulin aspart 30 injection plus metformin) were more in line with the minimum cost principle of pharmacoeconomics, and worth being advocated.