CAJ | 학술논문

目的：探讨三种抗幽门螺杆菌法治疗复发性口腔溃疡（ROU）的疗效。方法选择幽门螺杆菌唾液测试板（HPS）检测阳性的ROU患者159例，分为A、B、C三组，各组处理措施为：A组：复方氯己定含漱液含漱；B组：A组处理方法＋牙周洁治；C组：B组处理方法＋三联药物（枸橼酸泌钾颗粒、克拉霉素片、替硝唑片）；观察三组患者的治疗期疗效和治疗后3个月疗效。结果三组患者平均溃疡期、疼痛指数和间歇期均有统计学差异（P＜0.05），其中C组改善最明显；总溃疡数组间无统计学差异（P＞0.05）。结论联合使用含漱液、牙周洁治和三联药物治疗HPS阳性ROU有明显疗效，提示ROU和幽门螺杆菌可能有关。
목적：탐토삼충항유문라간균법치료복발성구강궤양（ROU）적료효。방법선택유문라간균타액측시판（HPS）검측양성적ROU환자159례，분위A、B、C삼조，각조처리조시위：A조：복방록기정함수액함수；B조：A조처리방법＋아주길치；C조：B조처리방법＋삼련약물（구연산비갑과립、극랍매소편、체초서편）；관찰삼조환자적치료기료효화치료후3개월료효。결과삼조환자평균궤양기、동통지수화간헐기균유통계학차이（P＜0.05），기중C조개선최명현；총궤양수조간무통계학차이（P＞0.05）。결론연합사용함수액、아주길치화삼련약물치료HPS양성ROU유명현료효，제시ROU화유문라간균가능유관。
ObjectiveTo investigate the effects of three anti-H.pylori treatments to recurrent oral ulcer(ROU).Methods159 ROU patients tested positive using H.pylori Saliva Test Cassette (HPS) were collected and divided into group A, B, C. Treatment measures were as follows: group A: compound chlorhexidine gargle; group B: A+periodontal scaling; group C: B+triple-drug (potassium citrate secretion granules, clarithromycin tablets, tinidazole tablets).Results The duration, pain and interval of ulcers of three groups' patients were different (P<0.05), of which the most remarkable improvement in group C; no difference between the total array of ulcers (P>0.05).Conclusion The combined treatment effect of gargle, periodontal scaling and triple drug therapy for HPS positive ROU patients is significant effect, suggesting ROU and H. pylori may have a relationship.